PDLIM7

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PDLIM7
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PDLIM7, LMP1, LMP3, PDZ and LIM domain 7
External IDs MGI: 1914649 HomoloGene: 3980 GeneCards: PDLIM7
RNA expression pattern
PBB GE PDLIM7 203370 s at fs.png

PBB GE PDLIM7 203369 x at fs.png

PBB GE PDLIM7 214266 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005451
NM_203352
NM_203353
NM_213636

NM_001114087
NM_001114088
NM_026131

RefSeq (protein)

NP_005442
NP_976227
NP_998801

NP_001107560.1
NP_080407.3
NP_001107559
NP_001107560
NP_080407

Location (UCSC) Chr 5: 177.48 – 177.5 Mb Chr 13: 55.5 – 55.51 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

PDZ and LIM domain protein 7 is a protein that in humans is encoded by the PDLIM7 gene.[3][4]

The protein encoded by this gene is representative of a family of proteins composed of conserved PDZ and LIM domains. LIM domains are proposed to function in protein–protein recognition in a variety of contexts including gene transcription and development and in cytoskeletal interaction. The LIM domains of this protein bind to protein kinases, whereas the PDZ domain binds to actin filaments. The gene product is involved in the assembly of an actin filament-associated complex essential for transmission of ret/ptc2 mitogenic signaling. The biological function is likely to be that of an adapter, with the PDZ domain localizing the LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Alternative splicing of this gene results in multiple transcript variants.[4]

Interactions[edit]

PDLIM7 has been shown to interact with TPM2.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Liu Y, Hair GA, Boden SD, Viggeswarapu M, Titus L (Mar 2002). "Overexpressed LIM mineralization proteins do not require LIM domains to induce bone". J Bone Miner Res. 17 (3): 406–14. doi:10.1359/jbmr.2002.17.3.406. PMID 11874232. 
  4. ^ a b "Entrez Gene: PDLIM7 PDZ and LIM domain 7 (enigma)". 
  5. ^ Guy, P M; Kenny D A; Gill G N (Jun 1999). "The PDZ domain of the LIM protein enigma binds to beta-tropomyosin". Mol. Biol. Cell. UNITED STATES. 10 (6): 1973–84. doi:10.1091/mbc.10.6.1973. ISSN 1059-1524. PMC 25398Freely accessible. PMID 10359609. 

Further reading[edit]