PDSS2

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PDSS2
Identifiers
AliasesPDSS2, C6orf210, COQ10D3, DLP1, bA59I9.3, hDLP1, prenyl (decaprenyl) diphosphate synthase, subunit 2, decaprenyl diphosphate synthase subunit 2, COQ1B
External IDsOMIM: 610564 MGI: 1918615 HomoloGene: 56885 GeneCards: PDSS2
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for PDSS2
Genomic location for PDSS2
Band6q21Start107,152,562 bp[1]
End107,459,564 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_020381

NM_001168289
NM_027772

RefSeq (protein)

NP_065114

NP_001161761
NP_082048

Location (UCSC)Chr 6: 107.15 – 107.46 MbChr 10: 43.22 – 43.46 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Decaprenyl-diphosphate synthase subunit 2 (PDSS2) is a protein that in humans is encoded by the PDSS2 gene.[5]

Function[edit]

The protein encoded by this gene is an enzyme that synthesizes the prenyl side-chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain. The gene product catalyzes the formation of all trans-polyprenyl pyrophosphates from isopentyl diphosphate in the assembly of polyisoprenoid side chains, the first step in coenzyme Q biosynthesis.[5]

Clinical significance[edit]

It may be associated with Coenzyme Q10 deficiency.[6]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164494 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038240 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: prenyl (decaprenyl) diphosphate synthase".
  6. ^ Online Mendelian Inheritance in Man (OMIM) 607426

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.