PD 144418

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PD 144418
PD144418.png
Identifiers
CAS Number
ChemSpider
Chemical and physical data
Formula C18H22N2O
Molar mass 282.38 g/mol
3D model (JSmol)

PD 144418 or 1,2,3,6-tetrahydro-5-[3-(4-methylphenyl)-5-isoxazolyl]-1-propylpyridine is a potent and selective ligand for the sigma-1 receptor, with a reported binding affinity of Ki = 0.08 ± 0.01 nM, and 17 212 times selectivity over the sigma-2 receptor.[1]

References[edit]

  1. ^ Akunne HC, Whetzel SZ, Wiley JN, Corbin AE, Ninteman FW, Tecle H, Pei Y, Pugsley TA, Heffner TG (January 1997). "The pharmacology of the novel and selective sigma ligand, PD 144418". Neuropharmacology. 36 (1): 51–62. PMID 9144641. doi:10.1016/S0028-3908(96)00161-X.