PEX14

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PEX14
Protein PEX14 PDB 2W84.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PEX14, NAPP2, PBD13A, Pex14p, dJ734G22.2, peroxisomal biogenesis factor 14
External IDs MGI: 1927868 HomoloGene: 37936 GeneCards: 5195
Genetically Related Diseases
Disease Name References
breast cancer
RNA expression pattern
PBB GE PEX14 203503 s at tn.png

PBB GE PEX14 33760 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004565

NM_019781

RefSeq (protein)

NP_004556.1

NP_062755.1

Location (UCSC) Chr 1: 10.47 – 10.63 Mb Chr 4: 148.96 – 149.1 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse
Peroxisomal membrane anchor protein (Pex14p) conserved region
Identifiers
Symbol Pex14_N
Pfam PF04695
InterPro IPR006785

Peroxisomal membrane protein PEX14 is a protein that in humans is encoded by the PEX14 gene.[4][5]

Function[edit]

This gene encodes an essential component of the peroxisomal import machinery. The protein is integrated into peroxisome membranes with its C-terminus exposed to the cytosol, and interacts with the cytosolic receptor for proteins containing a PTS1 peroxisomal targeting signal. The protein also functions as a transcriptional corepressor and interacts with a histone deacetylase. A mutation in this gene results in one form of Zellweger syndrome.[5]

Interactions[edit]

PEX14 has been shown to interact with

References[edit]

  1. ^ "chibi.ubc.ca/Gemma/phenotypes.html?phenotypeUrlId=DOID_1612&geneId=124146". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Fransen M, Terlecky SR, Subramani S (Jul 1998). "Identification of a human PTS1 receptor docking protein directly required for peroxisomal protein import". Proceedings of the National Academy of Sciences of the United States of America. 95 (14): 8087–92. doi:10.1073/pnas.95.14.8087. PMC 20933free to read. PMID 9653144. 
  5. ^ a b "Entrez Gene: PEX14 peroxisomal biogenesis factor 14". 
  6. ^ a b Otera H, Setoguchi K, Hamasaki M, Kumashiro T, Shimizu N, Fujiki Y (Mar 2002). "Peroxisomal targeting signal receptor Pex5p interacts with cargoes and import machinery components in a spatiotemporally differentiated manner: conserved Pex5p WXXXF/Y motifs are critical for matrix protein import". Molecular and Cellular Biology. 22 (6): 1639–55. doi:10.1128/MCB.22.6.1639-1655.2002. PMC 135613free to read. PMID 11865044. 
  7. ^ Okumoto K, Abe I, Fujiki Y (Aug 2000). "Molecular anatomy of the peroxin Pex12p: ring finger domain is essential for Pex12p function and interacts with the peroxisome-targeting signal type 1-receptor Pex5p and a ring peroxin, Pex10p". The Journal of Biological Chemistry. 275 (33): 25700–10. doi:10.1074/jbc.M003303200. PMID 10837480. 
  8. ^ Shimizu N, Itoh R, Hirono Y, Otera H, Ghaedi K, Tateishi K, Tamura S, Okumoto K, Harano T, Mukai S, Fujiki Y (Apr 1999). "The peroxin Pex14p. cDNA cloning by functional complementation on a Chinese hamster ovary cell mutant, characterization, and functional analysis". The Journal of Biological Chemistry. 274 (18): 12593–604. doi:10.1074/jbc.274.18.12593. PMID 10212238. 
  9. ^ a b Managadze D, Würtz C, Sichting M, Niehaus G, Veenhuis M, Rottensteiner H (Jun 2007). "The peroxin PEX14 of Neurospora crassa is essential for the biogenesis of both glyoxysomes and Woronin bodies". Traffic. 8 (6): 687–701. doi:10.1111/j.1600-0854.2007.00560.x. PMID 17461798. 

Further reading[edit]

External links[edit]