PEX16

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PEX16
Identifiers
Aliases PEX16, PBD8A, PBD8B, peroxisomal biogenesis factor 16
External IDs MGI: 1338829 HomoloGene: 3537 GeneCards: 9409
RNA expression pattern
PBB GE PEX16 221603 at tn.png

PBB GE PEX16 221604 s at tn.png

PBB GE PEX16 49878 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004813
NM_057174

NM_145122

RefSeq (protein)

NP_004804.1
NP_476515.1

NP_660104.2

Location (UCSC) Chr 11: 45.91 – 45.92 Mb Chr 2: 92.37 – 92.38 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Peroxisomal membrane protein PEX16 is a protein that in humans is encoded by the PEX16 gene.[1][2]

Function[edit]

The protein encoded by this gene is an integral peroxisomal membrane protein. An inactivating nonsense mutation localized to this gene was observed in a patient with Zellweger syndrome of the complementation group CGD/CG9. Expression of this gene product morphologically and biochemically restores the formation of new peroxisomes, suggesting a role in peroxisome organization and biogenesis. Alternative splicing has been observed for this gene and two variants have been described.[2]

Interactions[edit]

PEX16 has been shown to interact with PEX19.[3]

References[edit]

  1. ^ South ST, Gould SJ (Mar 1999). "Peroxisome Synthesis in the Absence of Preexisting Peroxisomes". J Cell Biol 144 (2): 255–66. doi:10.1083/jcb.144.2.255. PMC 2132891. PMID 9922452. 
  2. ^ a b "Entrez Gene: PEX16 peroxisomal biogenesis factor 16". 
  3. ^ Fransen, M; Wylin T; Brees C; Mannaerts G P; Van Veldhoven P P (Jul 2001). "Human Pex19p Binds Peroxisomal Integral Membrane Proteins at Regions Distinct from Their Sorting Sequences". Mol. Cell. Biol. (United States) 21 (13): 4413–24. doi:10.1128/MCB.21.13.4413-4424.2001. ISSN 0270-7306. PMC 87101. PMID 11390669. 

Further reading[edit]

External links[edit]