PEX5

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PEX5
Protein PEX5 PDB 1fch.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPEX5, PBD2A, PBD2B, PTS1-BP, PTS1R, PXR1, RCDP5, peroxisomal biogenesis factor 5
External IDsMGI: 1098808 HomoloGene: 270 GeneCards: PEX5
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for PEX5
Genomic location for PEX5
Band12p13.31Start7,188,685 bp[1]
End7,218,574 bp[1]
RNA expression pattern
PBB GE PEX5 215481 s at fs.png

PBB GE PEX5 203244 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001277330
NM_001277805
NM_008995
NM_175933
NM_001360570

RefSeq (protein)

NP_001264259
NP_001264734
NP_033021
NP_787947
NP_001347499

Location (UCSC)Chr 12: 7.19 – 7.22 MbChr 6: 124.4 – 124.42 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Peroxisomal targeting signal 1 receptor is a protein that in humans is encoded by the PEX5 gene.[5]

Interactions[edit]

PEX5 has been shown to interact with PEX12,[6][7] PEX13[8][9] and PEX14.[7][9][10]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000139197 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005069 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ "Entrez Gene: PEX5 Peroxisomal biogenesis factor 5".
  6. ^ Chang CC, Warren DS, Sacksteder KA, Gould SJ (Nov 1999). "PEX12 interacts with PEX5 and PEX10 and acts downstream of receptor docking in peroxisomal matrix protein import". The Journal of Cell Biology. 147 (4): 761–74. doi:10.1083/jcb.147.4.761. PMC 2156163. PMID 10562279.
  7. ^ a b Okumoto K, Abe I, Fujiki Y (Aug 2000). "Molecular anatomy of the peroxin Pex12p: ring finger domain is essential for Pex12p function and interacts with the peroxisome-targeting signal type 1-receptor Pex5p and a ring peroxin, Pex10p". The Journal of Biological Chemistry. 275 (33): 25700–10. doi:10.1074/jbc.M003303200. PMID 10837480.
  8. ^ Gould SJ, Kalish JE, Morrell JC, Bjorkman J, Urquhart AJ, Crane DI (Oct 1996). "Pex13p is an SH3 protein of the peroxisome membrane and a docking factor for the predominantly cytoplasmic PTs1 receptor". The Journal of Cell Biology. 135 (1): 85–95. doi:10.1083/jcb.135.1.85. PMC 2121023. PMID 8858165.
  9. ^ a b Otera H, Setoguchi K, Hamasaki M, Kumashiro T, Shimizu N, Fujiki Y (Mar 2002). "Peroxisomal targeting signal receptor Pex5p interacts with cargoes and import machinery components in a spatiotemporally differentiated manner: conserved Pex5p WXXXF/Y motifs are critical for matrix protein import". Molecular and Cellular Biology. 22 (6): 1639–55. doi:10.1128/MCB.22.6.1639-1655.2002. PMC 135613. PMID 11865044.
  10. ^ Shimizu N, Itoh R, Hirono Y, Otera H, Ghaedi K, Tateishi K, Tamura S, Okumoto K, Harano T, Mukai S, Fujiki Y (Apr 1999). "The peroxin Pex14p. cDNA cloning by functional complementation on a Chinese hamster ovary cell mutant, characterization, and functional analysis". The Journal of Biological Chemistry. 274 (18): 12593–604. doi:10.1074/jbc.274.18.12593. PMID 10212238.

Further reading[edit]

External links[edit]