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Peroxisomal biogenesis factor 5
Protein PEX5 PDB 1fch.png
PDB rendering based on 1fch.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PEX5 ; PBD2A; PBD2B; PTS1-BP; PTS1R; PXR1
External IDs OMIM600414 MGI1098808 HomoloGene270 GeneCards: PEX5 Gene
RNA expression pattern
PBB GE PEX5 203244 at tn.png
PBB GE PEX5 215481 s at tn.png
More reference expression data
Species Human Mouse
Entrez 5830 19305
Ensembl ENSG00000139197 ENSMUSG00000005069
UniProt P50542 O09012
RefSeq (mRNA) NM_000319 NM_001277330
RefSeq (protein) NP_000310 NP_001264259
Location (UCSC) Chr 12:
7.34 – 7.37 Mb
Chr 6:
124.4 – 124.42 Mb
PubMed search [1] [2]

Peroxisomal targeting signal 1 receptor is a protein that in humans is encoded by the PEX5 gene.[1]


PEX5 has been shown to interact with PEX12,[2][3] PEX13[4][5] and PEX14.[3][5][6]


  1. ^ "Entrez Gene: PEX5 Peroxisomal biogenesis factor 5". 
  2. ^ Chang, C C; Warren D S; Sacksteder K A; Gould S J (November 1999). "Pex12 Interacts with Pex5 and Pex10 and Acts Downstream of Receptor Docking in Peroxisomal Matrix Protein Import". J. Cell Biol. (UNITED STATES) 147 (4): 761–74. doi:10.1083/jcb.147.4.761. ISSN 0021-9525. PMC 2156163. PMID 10562279. 
  3. ^ a b Okumoto, K; Abe I; Fujiki Y (August 2000). "Molecular anatomy of the peroxin Pex12p: ring finger domain is essential for Pex12p function and interacts with the peroxisome-targeting signal type 1-receptor Pex5p and a ring peroxin, Pex10p". J. Biol. Chem. (UNITED STATES) 275 (33): 25700–10. doi:10.1074/jbc.M003303200. ISSN 0021-9258. PMID 10837480. 
  4. ^ Gould, S J; Kalish J E; Morrell J C; Bjorkman J; Urquhart A J; Crane D I (October 1996). "Pex13p is an SH3 protein of the peroxisome membrane and a docking factor for the predominantly cytoplasmic PTs1 receptor". J. Cell Biol. (UNITED STATES) 135 (1): 85–95. doi:10.1083/jcb.135.1.85. ISSN 0021-9525. PMC 2121023. PMID 8858165. 
  5. ^ a b Otera, Hidenori; Setoguchi Kiyoko; Hamasaki Maho; Kumashiro Toshitaka; Shimizu Nobuhiro; Fujiki Yukio (March 2002). "Peroxisomal Targeting Signal Receptor Pex5p Interacts with Cargoes and Import Machinery Components in a Spatiotemporally Differentiated Manner: Conserved Pex5p WXXXF/Y Motifs Are Critical for Matrix Protein Import". Mol. Cell. Biol. (United States) 22 (6): 1639–55. doi:10.1128/MCB.22.6.1639-1655.2002. ISSN 0270-7306. PMC 135613. PMID 11865044. 
  6. ^ Shimizu, N; Itoh R, Hirono Y, Otera H, Ghaedi K, Tateishi K, Tamura S, Okumoto K, Harano T, Mukai S, Fujiki Y (April 1999). "The peroxin Pex14p. cDNA cloning by functional complementation on a Chinese hamster ovary cell mutant, characterization, and functional analysis". J. Biol. Chem. (UNITED STATES) 274 (18): 12593–604. doi:10.1074/jbc.274.18.12593. ISSN 0021-9258. PMID 10212238. 

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