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Peroxisomal biogenesis factor 5
Protein PEX5 PDB 1fch.png
PDB rendering based on 1fch.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PEX5 ; PBD2A; PBD2B; PTS1-BP; PTS1R; PXR1
External IDs OMIM600414 MGI1098808 HomoloGene270 GeneCards: PEX5 Gene
RNA expression pattern
PBB GE PEX5 203244 at tn.png
PBB GE PEX5 215481 s at tn.png
More reference expression data
Species Human Mouse
Entrez 5830 19305
Ensembl ENSG00000139197 ENSMUSG00000005069
UniProt P50542 O09012
RefSeq (mRNA) NM_000319 NM_001277330
RefSeq (protein) NP_000310 NP_001264259
Location (UCSC) Chr 12:
7.19 – 7.22 Mb
Chr 6:
124.4 – 124.42 Mb
PubMed search [1] [2]

Peroxisomal targeting signal 1 receptor is a protein that in humans is encoded by the PEX5 gene.[1]


PEX5 has been shown to interact with PEX12,[2][3] PEX13[4][5] and PEX14.[3][5][6]


  1. ^ "Entrez Gene: PEX5 Peroxisomal biogenesis factor 5". 
  2. ^ Chang CC, Warren DS, Sacksteder KA, Gould SJ (Nov 1999). "PEX12 interacts with PEX5 and PEX10 and acts downstream of receptor docking in peroxisomal matrix protein import". The Journal of Cell Biology 147 (4): 761–74. doi:10.1083/jcb.147.4.761. PMC 2156163. PMID 10562279. 
  3. ^ a b Okumoto K, Abe I, Fujiki Y (Aug 2000). "Molecular anatomy of the peroxin Pex12p: ring finger domain is essential for Pex12p function and interacts with the peroxisome-targeting signal type 1-receptor Pex5p and a ring peroxin, Pex10p". The Journal of Biological Chemistry 275 (33): 25700–10. doi:10.1074/jbc.M003303200. PMID 10837480. 
  4. ^ Gould SJ, Kalish JE, Morrell JC, Bjorkman J, Urquhart AJ, Crane DI (Oct 1996). "Pex13p is an SH3 protein of the peroxisome membrane and a docking factor for the predominantly cytoplasmic PTs1 receptor". The Journal of Cell Biology 135 (1): 85–95. doi:10.1083/jcb.135.1.85. PMC 2121023. PMID 8858165. 
  5. ^ a b Otera H, Setoguchi K, Hamasaki M, Kumashiro T, Shimizu N, Fujiki Y (Mar 2002). "Peroxisomal targeting signal receptor Pex5p interacts with cargoes and import machinery components in a spatiotemporally differentiated manner: conserved Pex5p WXXXF/Y motifs are critical for matrix protein import". Molecular and Cellular Biology 22 (6): 1639–55. doi:10.1128/MCB.22.6.1639-1655.2002. PMC 135613. PMID 11865044. 
  6. ^ Shimizu N, Itoh R, Hirono Y, Otera H, Ghaedi K, Tateishi K, Tamura S, Okumoto K, Harano T, Mukai S, Fujiki Y (Apr 1999). "The peroxin Pex14p. cDNA cloning by functional complementation on a Chinese hamster ovary cell mutant, characterization, and functional analysis". The Journal of Biological Chemistry 274 (18): 12593–604. doi:10.1074/jbc.274.18.12593. PMID 10212238. 

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