Plasmepsin II

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Plasmepsin II
PDB 3f9q EBI.png
Identifiers
EC number 3.4.23.39
CAS number 159447-18-4
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Plasmepsin II (EC 3.4.23.39, aspartic hemoglobinase II, PFAPD) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction

Hydrolysis of the bonds linking certain hydrophobic residues in hemoglobin or globin. Also cleaves the small molecule substrates such as Ala-Leu-Glu-Arg-Thr-Phe-Phe(NO2)-Ser-Phe-Pro-Thr

This enzyme is present in malaria organism, Plasmodium.

References[edit]

  1. ^ Dame, J.B.; Reddy, G.R.; Yowell, C.A.; Dunn, B.M.; Kay, J.; Berry, C. (1994). "Sequence, expression and modelled structure of an aspartic proteinase from the human malaria parasite Plasmodium falciparum". Mol. Biochem. Parasitol. 64: 177–190. PMID 7935597. doi:10.1016/0166-6851(94)90024-8. 
  2. ^ Gluzman, I.Y.; Francis, S.E.; Oksman, A.; Smith, C.E.; Duffin, K.L.; Goldberg, D.E. (1994). "Order and specificity of the Plasmodium falciparum hemoglobin degradation pathway". J. Clin. Invest. 93 (4): 1602–1608. PMC 294190Freely accessible. PMID 8163662. doi:10.1172/JCI117140. 
  3. ^ Hill, J.; Tyas, L.; Phylip, L.H.; Kay, J.; Dunn, B.M.; Berry, C. (1994). "High level expression and characterisation of plasmepsin II, an aspartic proteinase from Plasmodium falciparum". FEBS Lett. 352 (2): 155–158. PMID 7925966. doi:10.1016/0014-5793(94)00940-6. 

External links[edit]