Plasmepsin II

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Plasmepsin II
PDB 3f9q EBI.png
EC number
CAS number 159447-18-4
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Plasmepsin II (EC, aspartic hemoglobinase II, PFAPD) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction

Hydrolysis of the bonds linking certain hydrophobic residues in hemoglobin or globin. Also cleaves the small molecule substrates such as Ala-Leu-Glu-Arg-Thr-Phe-Phe(NO2)-Ser-Phe-Pro-Thr

This enzyme is present in malaria organism, Plasmodium.


  1. ^ Dame, J.B.; Reddy, G.R.; Yowell, C.A.; Dunn, B.M.; Kay, J.; Berry, C. (1994). "Sequence, expression and modelled structure of an aspartic proteinase from the human malaria parasite Plasmodium falciparum". Mol. Biochem. Parasitol. 64: 177–190. PMID 7935597. doi:10.1016/0166-6851(94)90024-8. 
  2. ^ Gluzman, I.Y.; Francis, S.E.; Oksman, A.; Smith, C.E.; Duffin, K.L.; Goldberg, D.E. (1994). "Order and specificity of the Plasmodium falciparum hemoglobin degradation pathway". J. Clin. Invest. 93 (4): 1602–1608. PMC 294190Freely accessible. PMID 8163662. doi:10.1172/JCI117140. 
  3. ^ Hill, J.; Tyas, L.; Phylip, L.H.; Kay, J.; Dunn, B.M.; Berry, C. (1994). "High level expression and characterisation of plasmepsin II, an aspartic proteinase from Plasmodium falciparum". FEBS Lett. 352 (2): 155–158. PMID 7925966. doi:10.1016/0014-5793(94)00940-6. 

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