PFDN2

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PFDN2
Identifiers
AliasesPFDN2, PFD2, prefoldin subunit 2
External IDsOMIM: 613466 MGI: 1276111 HomoloGene: 7887 GeneCards: PFDN2
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for PFDN2
Genomic location for PFDN2
Band1q23.3Start161,100,556 bp[1]
End161,118,055 bp[1]
RNA expression pattern
PBB GE PFDN2 218336 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012394

NM_011070
NM_001360824
NM_001360825

RefSeq (protein)

NP_036526

NP_035200
NP_001347753
NP_001347754

Location (UCSC)Chr 1: 161.1 – 161.12 MbChr 1: 171.35 – 171.36 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Prefoldin subunit 2 is a protein that in humans is encoded by the PFDN2 gene.[5][6]

This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143256 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006412 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Eddleston J, Murdoch JN, Copp AJ, Stanier P (Apr 1999). "Physical and transcriptional map of a 3-Mb region of mouse chromosome 1 containing the gene for the neural tube defect mutant loop-tail (Lp)". Genomics. 56 (2): 149–59. doi:10.1006/geno.1998.5701. PMID 10051400.
  6. ^ a b "Entrez Gene: PFDN2 prefoldin subunit 2".

Further reading[edit]