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Prefoldin subunit 4
Symbols PFDN4 ; C1; PFD4
External IDs OMIM604898 MGI1923512 HomoloGene37645 GeneCards: PFDN4 Gene
RNA expression pattern
PBB GE PFDN4 205361 s at tn.png
PBB GE PFDN4 205362 s at tn.png
PBB GE PFDN4 205360 at tn.png
More reference expression data
Species Human Mouse
Entrez 5203 109054
Ensembl ENSG00000101132 ENSMUSG00000052033
UniProt Q9NQP4 E9Q4Q8
RefSeq (mRNA) NM_002623 NM_001013369
RefSeq (protein) NP_002614 NP_001013387
Location (UCSC) Chr 20:
54.21 – 54.23 Mb
Chr 2:
170.5 – 170.52 Mb
PubMed search [1] [2]

Prefoldin subunit 4 is a protein that in humans is encoded by the PFDN4 gene.[1][2][3]


This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils.[3]


  1. ^ Vainberg IE, Lewis SA, Rommelaere H, Ampe C, Vandekerckhove J, Klein HL, Cowan NJ (May 1998). "Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin". Cell 93 (5): 863–73. doi:10.1016/s0092-8674(00)81446-4. PMID 9630229. 
  2. ^ Iijima M, Kano Y, Nohno T, Namba M (Apr 1996). "Cloning of cDNA with possible transcription factor activity at the G1-S phase transition in human fibroblast cell lines". Acta Medica Okayama 50 (2): 73–7. PMID 8744932. 
  3. ^ a b Coraboeuf E, Deroubaix E, Hoerter J (May 1976). "Control of ionic permeabilities in normal and ischemic heart". Circulation Research 38 (5 Suppl 1): I92–8. PMID 5203. 

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