PFDN5

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PFDN5
Identifiers
Aliases PFDN5, MM-1, MM1, PFD5, prefoldin subunit 5
External IDs MGI: 1928753 HomoloGene: 1972 GeneCards: PFDN5
RNA expression pattern
PBB GE PFDN5 210908 s at fs.png

PBB GE PFDN5 207132 x at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_145897
NM_002624
NM_145896

NM_020031
NM_027044

RefSeq (protein)

NP_002615
NP_665904

NP_081320.2
NP_081320

Location (UCSC) Chr 12: 53.3 – 53.3 Mb Chr 15: 102.33 – 102.33 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Prefoldin subunit 5 is a protein that in humans is encoded by the PFDN5 gene.[3][4][5]

This gene encodes a member of the prefoldin alpha subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. The encoded protein may also repress the transcriptional activity of the proto-oncogene c-Myc. Alternatively spliced transcript variants encoding different isoforms have been described.[5]

Interactions[edit]

PFDN5 has been shown to interact with Myc.[4][6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Vainberg IE, Lewis SA, Rommelaere H, Ampe C, Vandekerckhove J, Klein HL, Cowan NJ (Jul 1998). "Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin". Cell. 93 (5): 863–873. doi:10.1016/S0092-8674(00)81446-4. PMID 9630229. 
  4. ^ a b Mori K, Maeda Y, Kitaura H, Taira T, Iguchi-Ariga SM, Ariga H (Dec 1998). "MM-1, a novel c-Myc-associating protein that represses transcriptional activity of c-Myc". J Biol Chem. 273 (45): 29794–29800. doi:10.1074/jbc.273.45.29794. PMID 9792694. 
  5. ^ a b "Entrez Gene: PFDN5 prefoldin subunit 5". 
  6. ^ Fujioka, Y; Taira T; Maeda Y; Tanaka S; Nishihara H; Iguchi-Ariga S M; Nagashima K; Ariga H (Nov 2001). "MM-1, a c-Myc-binding protein, is a candidate for a tumor suppressor in leukemia/lymphoma and tongue cancer". J. Biol. Chem. United States. 276 (48): 45137–45144. doi:10.1074/jbc.M106127200. ISSN 0021-9258. PMID 11567024. 

Further reading[edit]