PFKFB2

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PFKFB2
Identifiers
AliasesPFKFB2, PFK-2/FBPase-2, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
External IDsMGI: 107815 HomoloGene: 88554 GeneCards: PFKFB2
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for PFKFB2
Genomic location for PFKFB2
Band1q32.1Start207,034,366 bp[1]
End207,081,024 bp[1]
RNA expression pattern
PBB GE PFKFB2 207931 s at fs.png

PBB GE PFKFB2 209992 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001018053
NM_006212

NM_001162415
NM_001162416
NM_008825
NM_001368843

RefSeq (protein)

NP_001018063
NP_006203

NP_001155887
NP_001155888
NP_032851
NP_001355772

Location (UCSC)Chr 1: 207.03 – 207.08 MbChr 1: 130.69 – 130.73 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 is an enzyme that in humans is encoded by the PFKFB2 gene.[5]

The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene.[5]

Interactions[edit]

PFKFB2 has been shown to interact with YWHAQ.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000123836 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026409 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ a b "Entrez Gene: PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2".
  6. ^ Pozuelo Rubio, Mercedes; Peggie Mark; Wong Barry H C; Morrice Nick; MacKintosh Carol (Jul 2003). "14-3-3s regulate fructose-2,6-bisphosphate levels by binding to PKB-phosphorylated cardiac fructose-2,6-bisphosphate kinase/phosphatase". EMBO J. England. 22 (14): 3514–23. doi:10.1093/emboj/cdg363. ISSN 0261-4189. PMC 165633. PMID 12853467.

Further reading[edit]