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6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Protein PFKFB3 PDB 2axn.png
PDB rendering based on 2axn.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PFKFB3 ; IPFK2; PFK2
External IDs OMIM605319 MGI2181202 HomoloGene88708 GeneCards: PFKFB3 Gene
EC number,
RNA expression pattern
PBB GE PFKFB3 202464 s at tn.png
More reference expression data
Species Human Mouse
Entrez 5209 170768
Ensembl ENSG00000170525 ENSMUSG00000026773
UniProt Q16875 A2AUP1
RefSeq (mRNA) NM_001145443 NM_001177752
RefSeq (protein) NP_001138915 NP_001171223
Location (UCSC) Chr 10:
6.14 – 6.24 Mb
Chr 2:
11.47 – 11.55 Mb
PubMed search [1] [2]

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 is an enzyme that in humans is encoded by the PFKFB3 gene.[1][2][3]


  1. ^ Nicholl J, Hamilton JA, Sutherland GR, Sutherland RL, Watts CK (Jun 1997). "The third human isoform of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3) map position 10p14-p15". Chromosome Res 5 (2): 150. PMID 9146922. 
  2. ^ Manzano A, Rosa JL, Ventura F, Perez JX, Nadal M, Estivill X, Ambrosio S, Gil J, Bartrons R (Mar 1999). "Molecular cloning, expression, and chromosomal localization of a ubiquitously expressed human 6-phosphofructo-2-kinase/ fructose-2, 6-bisphosphatase gene (PFKFB3)". Cytogenet Cell Genet 83 (3–4): 214–7. doi:10.1159/000015181. PMID 10072580. 
  3. ^ "Entrez Gene: PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3". 

Further reading[edit]