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PFL may refer to:
- Perth Freight Link, transport route for trucks to access Fremantle port starting at Muchea in Western Australia.
- Pacific Forum Line, a shipping alliance located in Nauru
- Paid Family Leave (California), a California law that extends unemployment disability compensation
- Partido da Frente Liberal (Liberal Front Party (Brazil), a Brazilian political party
- Peel Football League, an Australian rules football league
- PFL, ISO 639-3 language code for the Palatine German language
- Pioneer Football League, an NCAA Division I-AA football conference
- Popular Front of Latvia, a former Latvian political party
- Pre-fader listen, a sound mixer function used for making a Fade (audio engineering)
- Priests for Life, an American-based Roman Catholic pro-life organization
- Professional Fighters League, an American mixed martial arts league.
- Professional Football League
- Professional Futsal League, an American sports league
- Philippines Football League, association football league in the Philippines
- Pyruvate formate lyase, an enzyme important in the regulation of anaerobic glucose metabolism
- Positive feedback loop
| disambiguation page lists articles associated with the title PFL.
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