PHLDA1

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PHLDA1
Identifiers
Aliases PHLDA1, DT1P1B11, PHRIP, TDAG51, pleckstrin homology like domain family A member 1
External IDs MGI: 1096880 HomoloGene: 7203 GeneCards: PHLDA1
RNA expression pattern
PBB GE PHLDA1 217996 at fs.png

PBB GE PHLDA1 217997 at fs.png

PBB GE PHLDA1 218000 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007350

NM_009344

RefSeq (protein)

NP_031376

NP_033370.2
NP_033370

Location (UCSC) Chr 12: 76.03 – 76.03 Mb Chr 10: 111.51 – 111.51 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Pleckstrin homology-like domain family A member 1 (PHLDA1) is a protein that in humans is encoded by the PHLDA1 gene.[3][4][5]

This gene encodes an evolutionarily conserved proline-histidine rich nuclear protein. The encoded protein may play an important role in the anti-apoptotic effects of insulin-like growth factor-1.[5]

Interactions[edit]

PHLDA1 has been shown to interact with RPL14,[6] EIF3D[6] and PABPC4.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Neef R, Kuske MA, Prols E, Johnson JP (Oct 2002). "Identification of the human PHLDA1/TDAG51 gene: down-regulation in metastatic melanoma contributes to apoptosis resistance and growth deregulation". Cancer Res. 62 (20): 5920–9. PMID 12384558. 
  4. ^ Toyoshima Y; Karas M; Yakar S; Dupont J; Lee Helman; LeRoith D (Jun 2004). "TDAG51 mediates the effects of insulin-like growth factor I (IGF-I) on cell survival". J Biol Chem. 279 (24): 25898–904. doi:10.1074/jbc.M400661200. PMID 15037619. 
  5. ^ a b "Entrez Gene: PHLDA1 pleckstrin homology-like domain, family A, member 1". 
  6. ^ a b c Hinz, T; Flindt S; Marx A; Janssen O; Kabelitz D (May 2001). "Inhibition of protein synthesis by the T cell receptor-inducible human TDAG51 gene product". Cell. Signal. England. 13 (5): 345–52. doi:10.1016/S0898-6568(01)00141-3. ISSN 0898-6568. PMID 11369516. 

Further reading[edit]