Pleckstrin homology-like domain family A member 2 is a protein that in humans is encoded by the PHLDA2gene.
This gene is one of several genes in the imprinted gene domain of 11p15.5, which is considered to be an important tumor suppressor gene region. Alterations in this region may be associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Studies of the mouse gene, however, which is also located in an imprinted gene domain, have shown that the product of this gene regulates placental growth.
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Müller S, van den Boom D, Zirkel D, et al. (2000). "Retention of imprinting of the human apoptosis-related gene TSSC3 in human brain tumors". Hum. Mol. Genet. 9 (5): 757–63. doi:10.1093/hmg/9.5.757. PMID10749982.
Saxena A, Frank D, Panichkul P, et al. (2004). "The product of the imprinted gene IPL marks human villous cytotrophoblast and is lost in complete hydatidiform mole". Placenta. 24 (8–9): 835–42. doi:10.1016/S0143-4004(03)00130-9. PMID13129680.
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Apostolidou S, Abu-Amero S, O'Donoghue K, et al. (2007). "Elevated placental expression of the imprinted PHLDA2 gene is associated with low birth weight". J. Mol. Med. 85 (4): 379–87. doi:10.1007/s00109-006-0131-8. PMID17180344.