PHTPP

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PHTPP
PHTPP structure.svg
Identifiers
CAS Number
PubChem CID
ChemSpider
Chemical and physical data
FormulaC20H11F6N3O
Molar mass423.311259 g/mol g·mol−1
3D model (JSmol)

PHTPP is a synthetic, nonsteroidal, and highly selective antagonist of ERβ that is used in scientific research to study the function of this receptor.[1][2] It possesses 36-fold selectivity for ERβ over ERα, and is a silent antagonist of ERβ.[3]

See also[edit]

References[edit]

  1. ^ Neurosteroids. Frontiers E-books. pp. 95–. ISBN 978-2-88919-078-2.
  2. ^ Cytoplasmic and Nuclear Receptors—Advances in Research and Application: 2012 Edition. ScholarlyEditions. 26 December 2012. pp. 220–. ISBN 978-1-4649-9741-9.
  3. ^ Compton DR, Sheng S, Carlson KE, Rebacz NA, Lee IY, Katzenellenbogen BS, Katzenellenbogen JA (2004). "Pyrazolo[1,5-a]pyrimidines: estrogen receptor ligands possessing estrogen receptor beta antagonist activity". J. Med. Chem. 47 (24): 5872–93. doi:10.1021/jm049631k. PMID 15537344.