From Wikipedia, the free encyclopedia
Jump to: navigation, search
Aliases PIAS4, PIASY, Piasg, ZMIZ6, PIAS-gamma, protein inhibitor of activated STAT 4
External IDs MGI: 2136940 HomoloGene: 104136 GeneCards: PIAS4
Gene location (Human)
Chromosome 19 (human)
Chr. Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for PIAS4
Genomic location for PIAS4
Band No data available Start 4,007,646 bp[1]
End 4,039,386 bp[1]
RNA expression pattern
PBB GE PIAS4 212879 x at fs.png

PBB GE PIAS4 212881 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 19: 4.01 – 4.04 Mb Chr 19: 81.15 – 81.17 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

E3 SUMO-protein ligase PIAS4 is one of several protein inhibitor of activated STAT (PIAS) proteins. It is also known as protein inhibitor of activated STAT protein gamma (PIASg or PIASy), and is an enzyme that in humans is encoded by the PIAS4 gene.[5][6]


PIAS4 has been shown to interact with Mothers against decapentaplegic homolog 6,[7] Mothers against decapentaplegic homolog 7[7] and Lymphoid enhancer-binding factor 1.[8]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000105229 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004934 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Liu B, Liao J, Rao X, Kushner SA, Chung CD, Chang DD, Shuai K (Sep 1998). "Inhibition of Stat1-mediated gene activation by PIAS1". Proc Natl Acad Sci U S A. 95 (18): 10626–31. PMC 27945Freely accessible. PMID 9724754. doi:10.1073/pnas.95.18.10626. 
  6. ^ "Entrez Gene: PIAS4 Protein inhibitor of activated STAT, 4". 
  7. ^ a b Imoto, Seiyu; Sugiyama Kenji; Muromoto Ryuta; Sato Noriko; Yamamoto Tetsuya; Matsuda Tadashi (Sep 2003). "Regulation of transforming growth factor-beta signaling by protein inhibitor of activated STAT, PIASy through Smad3". J. Biol. Chem. United States. 278 (36): 34253–8. ISSN 0021-9258. PMID 12815042. doi:10.1074/jbc.M304961200. 
  8. ^ Sachdev, S; Bruhn L; Sieber H; Pichler A; Melchior F; Grosschedl R (Dec 2001). "PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies". Genes Dev. United States. 15 (23): 3088–103. ISSN 0890-9369. PMC 312834Freely accessible. PMID 11731474. doi:10.1101/gad.944801. 

Further reading[edit]