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Protein inhibitor of activated STAT, 4
Symbols PIAS4 ; PIAS-gamma; PIASY; Piasg; ZMIZ6
External IDs OMIM605989 MGI2136940 HomoloGene104136 GeneCards: PIAS4 Gene
RNA expression pattern
PBB GE PIAS4 212881 at tn.png
PBB GE PIAS4 212879 x at tn.png
More reference expression data
Species Human Mouse
Entrez 51588 59004
Ensembl ENSG00000105229 ENSMUSG00000004934
UniProt Q8N2W9 Q9JM05
RefSeq (mRNA) NM_015897 NM_021501
RefSeq (protein) NP_056981 NP_067476
Location (UCSC) Chr 19:
4.01 – 4.04 Mb
Chr 10:
81.15 – 81.17 Mb
PubMed search [1] [2]

E3 SUMO-protein ligase PIAS4 is one of several protein inhibitor of activated STAT (PIAS) proteins. It is also known as protein inhibitor of activated STAT protein gamma (PIASg or PIASy), and is an enzyme that in humans is encoded by the PIAS4 gene.[1][2]


PIAS4 has been shown to interact with Mothers against decapentaplegic homolog 6,[3] Mothers against decapentaplegic homolog 7[3] and Lymphoid enhancer-binding factor 1.[4]


  1. ^ Liu B, Liao J, Rao X, Kushner SA, Chung CD, Chang DD, Shuai K (Sep 1998). "Inhibition of Stat1-mediated gene activation by PIAS1". Proc Natl Acad Sci U S A 95 (18): 10626–31. doi:10.1073/pnas.95.18.10626. PMC 27945. PMID 9724754. 
  2. ^ "Entrez Gene: PIAS4 Protein inhibitor of activated STAT, 4". 
  3. ^ a b Imoto, Seiyu; Sugiyama Kenji; Muromoto Ryuta; Sato Noriko; Yamamoto Tetsuya; Matsuda Tadashi (Sep 2003). "Regulation of transforming growth factor-beta signaling by protein inhibitor of activated STAT, PIASy through Smad3". J. Biol. Chem. (United States) 278 (36): 34253–8. doi:10.1074/jbc.M304961200. ISSN 0021-9258. PMID 12815042. 
  4. ^ Sachdev, S; Bruhn L; Sieber H; Pichler A; Melchior F; Grosschedl R (Dec 2001). "PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies". Genes Dev. (United States) 15 (23): 3088–103. doi:10.1101/gad.944801. ISSN 0890-9369. PMC 312834. PMID 11731474. 

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