PICALM

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PICALM
Protein PICALM PDB 1hf8.png
Identifiers
AliasesPICALM, CALM, CLTH, LAP, phosphatidylinositol binding clathrin assembly protein
External IDsMGI: 2385902 HomoloGene: 111783 GeneCards: PICALM
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for PICALM
Genomic location for PICALM
Band11q14.2Start85,957,684 bp[1]
End86,069,882 bp[1]
RNA expression pattern
PBB GE PICALM 212506 at fs.png

PBB GE PICALM 215236 s at fs.png

PBB GE PICALM 212511 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001008660
NM_001206946
NM_001206947
NM_007166

RefSeq (protein)

NP_001008660
NP_001193875
NP_001193876
NP_009097
NP_001008660.1

Location (UCSC)Chr 11: 85.96 – 86.07 MbChr 7: 90.13 – 90.21 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Phosphatidylinositol binding clathrin assembly protein, also known as PICALM, is a protein which in humans is encoded by the PICALM gene.[5]

Interactions[edit]

PICALM has been shown to interact with CLTC.[6]

Clinical significance[edit]

In humans, certain alleles of this gene have been statistically associated with an increased risk of developing late-onset Alzheimer's disease.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000073921 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039361 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ "Entrez Gene: PICALM phosphatidylinositol binding clathrin assembly protein".
  6. ^ Tebar, F; Bohlander S K; Sorkin A (Aug 1999). "Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic" (PDF). Mol. Biol. Cell. UNITED STATES. 10 (8): 2687–702. doi:10.1091/mbc.10.8.2687. ISSN 1059-1524. PMC 25500. PMID 10436022.
  7. ^ Harold D, Abraham R, Hollingworth P, et al. (September 2009). "Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease". Nat. Genet. 41 (10): 1088–93. doi:10.1038/ng.440. PMC 2845877. PMID 19734902. Lay summaryTIME Magazine (2009-09-06).

Further reading[edit]