PIGH

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PIGH
Identifiers
Aliases PIGH, GPI-H, phosphatidylinositol glycan anchor biosynthesis class H
External IDs MGI: 99463 HomoloGene: 3361 GeneCards: 5283
RNA expression pattern
PBB GE PIGH 209625 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004569

NM_029988

RefSeq (protein)

NP_004560.1

NP_084264.1

Location (UCSC) Chr 14: 67.58 – 67.6 Mb Chr 12: 79.08 – 79.09 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Phosphatidylinositol N-acetylglucosaminyltransferase subunit H is an enzyme that in humans is encoded by the PIGH gene.[1][2] The PIGH gene is located on the reverse strand of chromosome 14 in humans, and is neighbored by TMEM229B.[3]

This gene encodes an endoplasmic reticulum associated protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. The protein encoded by this gene is a subunit of the GPI N-acetylglucosaminyl (GlcNAc) transferase that transfers GlcNAc to phosphatidylinositol (PI) on the cytoplasmic side of the endoplasmic reticulum.[2]

Interactions[edit]

PIGH has been shown to interact with PIGQ.[4]

References[edit]

  1. ^ Ware RE, Howard TA, Kamitani T, Change HM, Yeh ET, Seldin MF (Jul 1994). "Chromosomal assignment of genes involved in glycosylphosphatidylinositol anchor biosynthesis: implications for the pathogenesis of paroxysmal nocturnal hemoglobinuria". Blood 83 (12): 3753–7. PMID 8204896. 
  2. ^ a b "Entrez Gene: PIGH phosphatidylinositol glycan anchor biosynthesis, class H". 
  3. ^ "AceView: Homo sapiens gene PIGH". AceView. National Library of Medicine. Retrieved 24 April 2011. 
  4. ^ Watanabe, R; Inoue N; Westfall B; Taron C H; Orlean P; Takeda J; Kinoshita T (Feb 1998). "The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1". EMBO J. (ENGLAND) 17 (4): 877–85. doi:10.1093/emboj/17.4.877. ISSN 0261-4189. PMC 1170437. PMID 9463366. 

Further reading[edit]