PIGQ

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PIGQ
Identifiers
Aliases PIGQ, GPI1, c407A10.1, phosphatidylinositol glycan anchor biosynthesis class Q
External IDs MGI: 1333114 HomoloGene: 31228 GeneCards: 9091
RNA expression pattern
PBB GE PIGQ 204144 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_148920
NM_004204

NM_001291025
NM_011822

RefSeq (protein)

NP_004195.2
NP_683721.1

NP_035952.2

Location (UCSC) Chr 16: 0.57 – 0.58 Mb Chr 17: 25.93 – 25.94 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q is an enzyme that in humans is encoded by the PIGQ gene.[1][2][3]

This gene is involved in the first step in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes a N-acetylglucosaminyl transferase component that is part of the complex that catalyzes transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI).[3]

Interactions[edit]

PIGQ has been shown to interact with PIGH,[1] PIGA[1] and PIGC.[1]

References[edit]

  1. ^ a b c d Watanabe R, Inoue N, Westfall B, Taron CH, Orlean P, Takeda J, Kinoshita T (Mar 1998). "The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1". EMBO J 17 (4): 877–85. doi:10.1093/emboj/17.4.877. PMC 1170437. PMID 9463366. 
  2. ^ Tiede A, Schubert J, Nischan C, Jensen I, Westfall B, Taron CH, Orlean P, Schmidt RE (Nov 1998). "Human and mouse Gpi1p homologues restore glycosylphosphatidylinositol membrane anchor biosynthesis in yeast mutants". Biochem J 334 (3): 609–16. PMC 1219730. PMID 9729469. 
  3. ^ a b "Entrez Gene: PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q". 

Further reading[edit]