PIGT

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PIGT
Identifiers
Aliases PIGT, MCAHS3, NDAP, PNH2, CGI-06, phosphatidylinositol glycan anchor biosynthesis class T
External IDs MGI: 1926178 HomoloGene: 6134 GeneCards: PIGT
RNA expression pattern
PBB GE PIGT 217770 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001184728
NM_001184729
NM_001184730
NM_015937

NM_133779

RefSeq (protein)

NP_001171657
NP_001171658
NP_001171659
NP_057021

NP_598540.2
NP_598540

Location (UCSC) Chr 20: 45.42 – 45.43 Mb Chr 2: 164.5 – 164.51 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

GPI transamidase component PIG-T is an enzyme that in humans is encoded by the PIGT gene.[3][4][5]

This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is an essential component of the multisubunit enzyme, GPI transamidase. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins.[4]

Interactions[edit]

PIGT has been shown to interact with PIGK[6] and GPAA1.[5][7]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Vainauskas S, Menon AK (Apr 2005). "Endoplasmic reticulum localization of Gaa1 and PIG-T, subunits of the glycosylphosphatidylinositol transamidase complex". J Biol Chem. 280 (16): 16402–9. doi:10.1074/jbc.M414253200. PMID 15713669. 
  4. ^ a b "Entrez Gene: PIGT phosphatidylinositol glycan anchor biosynthesis, class T". 
  5. ^ a b Ohishi K, Inoue N, Kinoshita T (August 2001). "PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8". EMBO J. 20 (15): 4088–98. doi:10.1093/emboj/20.15.4088. PMC 149153Freely accessible. PMID 11483512. 
  6. ^ Ohishi, Kazuhito; Nagamune Kisaburo; Maeda Yusuke; Kinoshita Taroh (Apr 2003). "Two subunits of glycosylphosphatidylinositol transamidase, GPI8 and PIG-T, form a functionally important intermolecular disulfide bridge". J. Biol. Chem. United States. 278 (16): 13959–67. doi:10.1074/jbc.M300586200. ISSN 0021-9258. PMID 12582175. 
  7. ^ Vainauskas, Saulius; Maeda Yusuke; Kurniawan Henry; Kinoshita Taroh; Menon Anant K (Aug 2002). "Structural requirements for the recruitment of Gaa1 into a functional glycosylphosphatidylinositol transamidase complex". J. Biol. Chem. United States. 277 (34): 30535–42. doi:10.1074/jbc.M205402200. ISSN 0021-9258. PMID 12052837. 

Further reading[edit]