PIGU

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PIGU
Identifiers
Aliases PIGU, CDC91L1, GAB1, phosphatidylinositol glycan anchor biosynthesis class U
External IDs MGI: 3039607 HomoloGene: 6553 GeneCards: PIGU
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_080476

NM_001004721

RefSeq (protein)

NP_536724

NP_001004721

Location (UCSC) Chr 20: 34.56 – 34.7 Mb Chr 2: 155.28 – 155.36 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Phosphatidylinositol glycan anchor biosynthesis class U protein is a protein that in humans is encoded by the PIGU gene.[3][4][5]

The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Cdc91, a predicted integral membrane protein that may function in cell division control. The protein encoded by this gene is the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Hong Y, Ohishi K, Kang JY, Tanaka S, Inoue N, Nishimura J, Maeda Y, Kinoshita T (Jun 2003). "Human PIG-U and yeast Cdc91p are the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins". Mol Biol Cell. 14 (5): 1780–9. doi:10.1091/mbc.E02-12-0794. PMC 165076Freely accessible. PMID 12802054. 
  4. ^ Guo Z, Linn JF, Wu G, Anzick SL, Eisenberger CF, Halachmi S, Cohen Y, Fomenkov A, Hoque MO, Okami K, Steiner G, Engles JM, Osada M, Moon C, Ratovitski E, Trent JM, Meltzer PS, Westra WH, Kiemeney LA, Schoenberg MP, Sidransky D, Trink B (Apr 2004). "CDC91L1 (PIG-U) is a newly discovered oncogene in human bladder cancer". Nat Med. 10 (4): 374–81. doi:10.1038/nm1010. PMID 15034568. 
  5. ^ a b "Entrez Gene: PIGU phosphatidylinositol glycan anchor biosynthesis, class U". 

Further reading[edit]