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Aliases PIK3C2B, C2-PI3K, phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
External IDs MGI: 2685045 HomoloGene: 20582 GeneCards: 5287
RNA expression pattern
PBB GE PIK3C2B 204484 at tn.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 1: 204.42 – 204.49 Mb Chr 1: 133.05 – 133.11 Mb
PubMed search [1] [2]
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Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide is an enzyme that in humans is encoded by the PIK3C2B gene.[1][2][3]


The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmannin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner.[3]


  1. ^ Brown RA, Ho LK, Weber-Hall SJ, Shipley JM, Fry MJ (Apr 1997). "Identification and cDNA cloning of a novel mammalian C2 domain-containing phosphoinositide 3-kinase, HsC2-PI3K". Biochemical and Biophysical Research Communications 233 (2): 537–44. doi:10.1006/bbrc.1997.6495. PMID 9144573. 
  2. ^ Arcaro A, Volinia S, Zvelebil MJ, Stein R, Watton SJ, Layton MJ, Gout I, Ahmadi K, Downward J, Waterfield MD (Dec 1998). "Human phosphoinositide 3-kinase C2beta, the role of calcium and the C2 domain in enzyme activity". The Journal of Biological Chemistry 273 (49): 33082–90. doi:10.1074/jbc.273.49.33082. PMID 9830063. 
  3. ^ a b "Entrez Gene: PIK3C2B phosphoinositide-3-kinase, class 2, beta polypeptide". 

Further reading[edit]