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Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PIK3C2G ; PI3K-C2-gamma; PI3K-C2GAMMA
External IDs OMIM609001 MGI1203730 HomoloGene3362 IUPHAR: 2288 ChEMBL: 1163120 GeneCards: PIK3C2G Gene
EC number
RNA expression pattern
PBB GE PIK3C2G 215129 at tn.png
More reference expression data
Species Human Mouse
Entrez 5288 18705
Ensembl ENSG00000139144 ENSMUSG00000030228
UniProt O75747 O70167
RefSeq (mRNA) NM_001288772 NM_011084
RefSeq (protein) NP_001275701 NP_035214
Location (UCSC) Chr 12:
18.25 – 18.65 Mb
Chr 6:
139.59 – 139.97 Mb
PubMed search [1] [2]

Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide is an enzyme that in humans is encoded by the PIK3C2G gene.[1][2]

The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The biological function of this gene has not yet been determined.[2]


  1. ^ Rozycka M, Lu YJ, Brown RA, Lau MR, Shipley JM, Fry MJ (Feb 1999). "cDNA cloning of a third human C2-domain-containing class II phosphoinositide 3-kinase, PI3K-C2gamma, and chromosomal assignment of this gene (PIK3C2G) to 12p12". Genomics 54 (3): 569–74. doi:10.1006/geno.1998.5621. PMID 9878262. 
  2. ^ a b "Entrez Gene: PIK3C2G phosphoinositide-3-kinase, class 2, gamma polypeptide". 

Further reading[edit]