PIK3CB

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PIK3CB
Identifiers
AliasesPIK3CB, P110BETA, PI3K, PI3KBETA, PIK3C1, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
External IDsOMIM: 602925 MGI: 1922019 HomoloGene: 21250 GeneCards: PIK3CB
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001256045
NM_006219

NM_029094

RefSeq (protein)

NP_001242974
NP_006210

NP_083370

Location (UCSC)Chr 3: 138.65 – 138.83 MbChr 9: 98.92 – 99.02 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform is an enzyme that in humans is encoded by the PIK3CB gene.[5][6]

Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. They have been implicated as participants in signaling pathways regulating cell growth by virtue of their activation in response to various mitogenic stimuli. PI3Ks are composed of a 110-kD catalytic subunit, such as PIK3CB, and an 85-kD adaptor subunit (Hu et al., 1993).[supplied by OMIM][6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000051382 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032462 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hu P, Mondino A, Skolnik EY, Schlessinger J (Jan 1994). "Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85". Mol Cell Biol. 13 (12): 7677–88. doi:10.1128/mcb.13.12.7677. PMC 364839. PMID 8246984.
  6. ^ a b "Entrez Gene: PIK3CB phosphoinositide-3-kinase, catalytic, beta polypeptide".

Further reading[edit]