PIR (gene)

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PIR
Protein PIR PDB 1j1l.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PIR
External IDs MGI: 1916906 HomoloGene: 2717 GeneCards: PIR
RNA expression pattern
PBB GE PIR 207469 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003662
NM_001018109

NM_001301402
NM_027153

RefSeq (protein)

NP_001018119
NP_003653

NP_081429.1
NP_001288331
NP_081429

Location (UCSC) Chr X: 15.38 – 15.49 Mb Chr X: 164.27 – 164.37 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Pirin is a protein that in humans is encoded by the PIR gene.[3][4]

This gene encodes a member of the cupin superfamily. The encoded protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. Alternatively spliced transcript variants have been described.[4]

Interactions[edit]

PIR (gene) has been shown to interact with BCL3.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Wendler WM, Kremmer E, Forster R, Winnacker EL (May 1997). "Identification of pirin, a novel highly conserved nuclear protein". J Biol Chem. 272 (13): 8482–9. doi:10.1074/jbc.272.13.8482. PMID 9079676. 
  4. ^ a b "Entrez Gene: PIR pirin (iron-binding nuclear protein)". 
  5. ^ Dechend, R; Hirano F; Lehmann K; Heissmeyer V; Ansieau S; Wulczyn F G; Scheidereit C; Leutz A (Jun 1999). "The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators". Oncogene. ENGLAND. 18 (22): 3316–23. doi:10.1038/sj.onc.1202717. ISSN 0950-9232. PMID 10362352. 

Further reading[edit]