PITPNM1

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PITPNM1
Identifiers
AliasesPITPNM1, DRES9, NIR2, PITPNM, RDGB, RDGB1, RDGBA, RDGBA1, Rd9, phosphatidylinositol transfer protein membrane associated 1
External IDsMGI: 1197524 HomoloGene: 3608 GeneCards: PITPNM1
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for PITPNM1
Genomic location for PITPNM1
Band11q13.2Start67,491,768 bp[1]
End67,506,263 bp[1]
RNA expression pattern
PBB GE PITPNM1 203826 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001130848
NM_004910

NM_001136078
NM_008851

RefSeq (protein)

NP_001124320
NP_004901

NP_032877

Location (UCSC)Chr 11: 67.49 – 67.51 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Membrane-associated phosphatidylinositol transfer protein 1 is a protein that in humans is encoded by the PITPNM1 gene.[4][5]

Function[edit]

PITPNM1 belongs to a family of proteins that share homology with the Drosophila retinal degeneration B (rdgB) protein.[supplied by OMIM][5]

It was found that aggressive metastasized cancer cells produced more of the PITPNC1 protein. In contrast, tumor cells that had not spread had lower expression of PITPNC1. Studies reveal that PITPNC1 promotes malignant secretion by binding Golgi-resident PI4P and localizing RAB1B to the Golgi. RAB1B localization to the Golgi allows for the recruitment of GOLPH3 (Golgi phosphoprotein 3), which facilitates Golgi extension and enhanced vesicular release. PITPNC1-mediated vesicular release drives metastasis by increasing the secretion of pro-invasive and pro-angiogenic mediators HTRA1, MMP1, FAM3C, PDGFA, and ADAM10.[6]

Interactions[edit]

PITPNM1 has been shown to interact with PTK2B.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000110697 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Rubboli F, Bulfone A, Bogni S, Marchitiello A, Zollo M, Borsani G, Ballabio A, Banfi S (1997). "A mammalian homologue of the Drosophila retinal degeneration B gene: implications for the evolution of phototransduction mechanisms". Genes Funct. 1 (3): 205–13. doi:10.1046/j.1365-4624.1997.00015.x. PMID 9680295. 
  5. ^ a b "Entrez Gene: PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1". 
  6. ^ Halberg N, Sengelaub CA, Navrazhina K, Molina H, Uryu K, Tavazoie SF (2016). "PITPNC1 Recruits RAB1B to the Golgi Network to Drive Malignant Secretion". Cancer Cell. 29 (3): 339–353. doi:10.1016/j.ccell.2016.02.013. PMID 26977884. 
  7. ^ Lev S, Hernandez J, Martinez R, Chen A, Plowman G, Schlessinger J (Mar 1999). "Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein". Mol. Cell. Biol. 19 (3): 2278–88. doi:10.1128/mcb.19.3.2278. PMC 84020Freely accessible. PMID 10022914. 

Further reading[edit]