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Polycystic kidney disease 2-like 1
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PKD2L1 ; PCL; PKD2L; PKDL; TRPP3
External IDs OMIM604532 MGI1352448 HomoloGene22946 IUPHAR: 505 ChEMBL: 1628480 GeneCards: PKD2L1 Gene
RNA expression pattern
PBB GE PKD2L1 221061 at tn.png
More reference expression data
Species Human Mouse
Entrez 9033 329064
Ensembl ENSG00000107593 ENSMUSG00000037578
UniProt Q9P0L9 A2A259
RefSeq (mRNA) NM_001253837 NM_181422
RefSeq (protein) NP_001240766 NP_852087
Location (UCSC) Chr 10:
100.29 – 100.33 Mb
Chr 19:
44.15 – 44.19 Mb
PubMed search [1] [2]

Polycystic kidney disease 2-like 1 protein also known as transient receptor potential polycystic 3 (TRPP3) is a protein that in humans is encoded by the PKD2L1 gene.[1]


TRPP3 is a member of the polycystin protein family. TRPP3 contains multiple transmembrane domains, and cytoplasmic N- and C-termini. TRPP3 may be an integral membrane protein involved in cell-cell/matrix interactions. TRPP3 functions as a calcium-regulated nonselective cation channel. Alternative splice variants have been described but their full length sequences have not been determined.[1]


PKD2L1 has been shown to interact with TNNI3.[2]

See also[edit]


  1. ^ a b "Entrez Gene: PKD2L1 polycystic kidney disease 2-like 1". 
  2. ^ Li Q, Liu Y, Shen PY, Dai XQ, Wang S, Smillie LB, Sandford R, Chen XZ (June 2003). "Troponin I binds polycystin-L and inhibits its calcium-induced channel activation". Biochemistry 42 (24): 7618–25. doi:10.1021/bi034210a. PMID 12809519. 

Further reading[edit]