PKD2L1

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PKD2L1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PKD2L1, PCL, PKD2L, PKDL, TRPP3, polycystin 2 like 1, transient receptor potential cation channel
External IDs MGI: 1352448 HomoloGene: 22946 GeneCards: PKD2L1
Genetically Related Diseases
obesity[1]
Targeted by Drug
citric acid, hydrogen chloride, malic acid, amiloride, benzamil, flufenamic acid[2]
RNA expression pattern
PBB GE PKD2L1 221061 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001253837
NM_016112

NM_181422

RefSeq (protein)

NP_001240766
NP_057196

NP_852087.2
NP_852087

Location (UCSC) Chr 10: 100.29 – 100.33 Mb Chr 19: 44.15 – 44.19 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Polycystic kidney disease 2-like 1 protein also known as transient receptor potential polycystic 3 (TRPP3) is a protein that in humans is encoded by the PKD2L1 gene.[5]

Function[edit]

TRPP3 is a member of the polycystin protein family. TRPP3 contains multiple transmembrane domains, and cytoplasmic N- and C-termini. TRPP3 may be an integral membrane protein involved in cell-cell/matrix interactions. TRPP3 functions as a calcium-regulated nonselective cation channel. Alternative splice variants have been described but their full length sequences have not been determined.[5]

Interactions[edit]

PKD2L1 has been shown to interact with TNNI3.[6]

See also[edit]

References[edit]

Further reading[edit]