PKD2L1

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PKD2L1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PKD2L1, PCL, PKD2L, PKDL, TRPP3, polycystin 2 like 1, transient receptor potential cation channel
External IDs MGI: 1352448 HomoloGene: 22946 GeneCards: 9033
Genetically Related Diseases
Disease Name References
obesity
RNA expression pattern
PBB GE PKD2L1 221061 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001253837
NM_016112

NM_181422

RefSeq (protein)

NP_001240766.1
NP_057196.2

NP_852087.2

Location (UCSC) Chr 10: 100.29 – 100.33 Mb Chr 19: 44.15 – 44.19 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Polycystic kidney disease 2-like 1 protein also known as transient receptor potential polycystic 3 (TRPP3) is a protein that in humans is encoded by the PKD2L1 gene.[4]

Function[edit]

TRPP3 is a member of the polycystin protein family. TRPP3 contains multiple transmembrane domains, and cytoplasmic N- and C-termini. TRPP3 may be an integral membrane protein involved in cell-cell/matrix interactions. TRPP3 functions as a calcium-regulated nonselective cation channel. Alternative splice variants have been described but their full length sequences have not been determined.[4]

Interactions[edit]

PKD2L1 has been shown to interact with TNNI3.[5]

See also[edit]

References[edit]

  1. ^ "chibi.ubc.ca/Gemma/phenotypes.html?phenotypeUrlId=DOID_9970&geneId=189103". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ a b "Entrez Gene: PKD2L1 polycystic kidney disease 2-like 1". 
  5. ^ Li Q, Liu Y, Shen PY, Dai XQ, Wang S, Smillie LB, Sandford R, Chen XZ (June 2003). "Troponin I binds polycystin-L and inhibits its calcium-induced channel activation". Biochemistry. 42 (24): 7618–25. doi:10.1021/bi034210a. PMID 12809519. 

Further reading[edit]