Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase is an enzyme that in humans is encoded by the PKMYT1gene.
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase preferentially phosphorylates and inactivates cell division cycle 2 protein (CDC2), and thus negatively regulates cell cycle G2/M transition. This kinase is associated with the membrane throughout the cell cycle. Its activity is highly regulated during the cell cycle. Protein kinases AKT1/PKB and PLK (Polo-like kinase) have been shown to phosphorylate and regulate the activity of this kinase. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Booher RN, Holman PS, Fattaey A (1997). "Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity". J. Biol. Chem. 272 (35): 22300–6. doi:10.1074/jbc.272.35.22300. PMID9268380.
Wells NJ, Watanabe N, Tokusumi T, et al. (1999). "The C-terminal domain of the Cdc2 inhibitory kinase Myt1 interacts with Cdc2 complexes and is required for inhibition of G(2)/M progression". J. Cell Sci. 112 (19): 3361–71. PMID10504341.
Okumura E, Fukuhara T, Yoshida H, et al. (2002). "Akt inhibits Myt1 in the signalling pathway that leads to meiotic G2/M-phase transition". Nat. Cell Biol. 4 (2): 111–6. doi:10.1038/ncb741. PMID11802161.
Nakajima H, Toyoshima-Morimoto F, Taniguchi E, Nishida E (2003). "Identification of a consensus motif for Plk (Polo-like kinase) phosphorylation reveals Myt1 as a Plk1 substrate". J. Biol. Chem. 278 (28): 25277–80. doi:10.1074/jbc.C300126200. PMID12738781.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
Dai X, Yamasaki K, Yang L, et al. (2004). "Keratinocyte G2/M growth arrest by 1,25-dihydroxyvitamin D3 is caused by Cdc2 phosphorylation through Wee1 and Myt1 regulation". J. Invest. Dermatol. 122 (6): 1356–64. doi:10.1111/j.0022-202X.2004.22522.x. PMID15175024.
Martin J, Han C, Gordon LA, et al. (2005). "The sequence and analysis of duplication-rich human chromosome 16". Nature. 432 (7020): 988–94. doi:10.1038/nature03187. PMID15616553.
Bryan BA, Dyson OF, Akula SM (2006). "Identifying cellular genes crucial for the reactivation of Kaposi's sarcoma-associated herpesvirus latency". J. Gen. Virol. 87 (Pt 3): 519–29. doi:10.1099/vir.0.81603-0. PMID16476973.
Wissing J, Jänsch L, Nimtz M, et al. (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry". Mol. Cell. Proteomics. 6 (3): 537–47. doi:10.1074/mcp.T600062-MCP200. PMID17192257.