PKMYT1

From Wikipedia, the free encyclopedia
  (Redirected from PKMYT1 (gene))
Jump to: navigation, search
PKMYT1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PKMYT1, MYT1, PPP1R126, protein kinase, membrane associated tyrosine/threonine 1
External IDs MGI: 2137630 HomoloGene: 31227 GeneCards: PKMYT1
Gene location (Human)
Chromosome 16 (human)
Chr. Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for PKMYT1
Genomic location for PKMYT1
Band 16p13.3 Start 2,968,024 bp[1]
End 2,980,539 bp[1]
RNA expression pattern
PBB GE PKMYT1 204267 x at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001258450
NM_001258451
NM_004203
NM_182687

NM_023058

RefSeq (protein)

NP_001245379
NP_001245380
NP_004194
NP_872629
NP_004194.3

NP_075545

Location (UCSC) Chr 16: 2.97 – 2.98 Mb Chr 16: 23.73 – 23.74 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase is an enzyme that in humans is encoded by the PKMYT1 gene.[5][6][7]

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase preferentially phosphorylates and inactivates cell division cycle 2 protein (CDC2), and thus negatively regulates cell cycle G2/M transition. This kinase is associated with the membrane throughout the cell cycle. Its activity is highly regulated during the cell cycle. Protein kinases AKT1/PKB and PLK (Polo-like kinase) have been shown to phosphorylate and regulate the activity of this kinase. Alternatively spliced transcript variants encoding distinct isoforms have been reported.[7]

Interactions[edit]

PKMYT1 has been shown to interact with PIN1[8] and STEAP3.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000127564 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023908 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Liu F, Stanton JJ, Wu Z, Piwnica-Worms H (Feb 1997). "The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex". Mol Cell Biol. 17 (2): 571–83. doi:10.1128/mcb.17.2.571. PMC 231782Freely accessible. PMID 9001210. 
  6. ^ a b Passer BJ, Nancy-Portebois V, Amzallag N, Prieur S, Cans C, Roborel de Climens A, Fiucci G, Bouvard V, Tuynder M, Susini L, Morchoisne S, Crible V, Lespagnol A, Dausset J, Oren M, Amson R, Telerman A (Mar 2003). "The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase". Proc Natl Acad Sci U S A. 100 (5): 2284–9. doi:10.1073/pnas.0530298100. PMC 151332Freely accessible. PMID 12606722. 
  7. ^ a b "Entrez Gene: PKMYT1 protein kinase, membrane associated tyrosine/threonine 1". 
  8. ^ Shen, M; Stukenberg P T; Kirschner M W; Lu K P (Mar 1998). "The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins". Genes Dev. UNITED STATES. 12 (5): 706–20. doi:10.1101/gad.12.5.706. ISSN 0890-9369. PMC 316589Freely accessible. PMID 9499405. 

Further reading[edit]