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Protein kinase N2
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PKN2 ; PAK2; PRK2; PRKCL2; PRO2042; Pak-2; STK7
External IDs OMIM602549 MGI109211 HomoloGene2054 ChEMBL: 3032 GeneCards: PKN2 Gene
EC number
RNA expression pattern
PBB GE PKN2 210969 at tn.png
PBB GE PKN2 212628 at tn.png
PBB GE PKN2 212629 s at tn.png
More reference expression data
Species Human Mouse
Entrez 5586 109333
Ensembl ENSG00000065243 ENSMUSG00000004591
UniProt Q16513 Q8BWW9
RefSeq (mRNA) NM_006256 NM_178654
RefSeq (protein) NP_006247 NP_848769
Location (UCSC) Chr 1:
88.68 – 88.84 Mb
Chr 3:
142.79 – 142.88 Mb
PubMed search [1] [2]

Serine/threonine-protein kinase N2 is an enzyme that in humans is encoded by the PKN2 gene.[1][2][3]


PKN2 has been shown to interact with:

Further reading[edit]


  1. ^ Palmer RH, Ridden J, Parker PJ (January 1995). "Identification of multiple, novel, protein kinase C-related gene products". FEBS Lett 356 (1): 5–8. doi:10.1016/0014-5793(94)01202-4. PMID 7988719. 
  2. ^ Palmer RH, Ridden J, Parker PJ (March 1995). "Cloning and expression patterns of two members of a novel protein-kinase-C-related kinase family". Eur J Biochem 227 (1–2): 344–351. doi:10.1111/j.1432-1033.1995.tb20395.x. PMID 7851406. 
  3. ^ "Entrez Gene: PKN2 protein kinase N2". 
  4. ^ Koh H, Lee KH, Kim D, Kim S, Kim JW, Chung J (November 2000). "Inhibition of Akt and its anti-apoptotic activities by tumor necrosis factor-induced protein kinase C-related kinase 2 (PRK2) cleavage". J. Biol. Chem. 275 (44): 34451–8. doi:10.1074/jbc.M001753200. PMID 10926925. 
  5. ^ a b Quilliam LA, Lambert QT, Mickelson-Young LA, Westwick JK, Sparks AB, Kay BK, Jenkins NA, Gilbert DJ, Copeland NG, Der CJ (November 1996). "Isolation of a NCK-associated kinase, PRK2, an SH3-binding protein and potential effector of Rho protein signaling". J. Biol. Chem. 271 (46): 28772–6. doi:10.1074/jbc.271.46.28772. PMID 8910519. 
  6. ^ Braverman LE, Quilliam LA (February 1999). "Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck". J. Biol. Chem. 274 (9): 5542–9. doi:10.1074/jbc.274.9.5542. PMID 10026169. 
  7. ^ Gross C, Heumann R, Erdmann KS (May 2001). "The protein kinase C-related kinase PRK2 interacts with the protein tyrosine phosphatase PTP-BL via a novel PDZ domain binding motif". FEBS Lett. 496 (2-3): 101–4. doi:10.1016/s0014-5793(01)02401-2. PMID 11356191. 
  8. ^ Hodgkinson CP, Sale GJ (January 2002). "Regulation of both PDK1 and the phosphorylation of PKC-zeta and -delta by a C-terminal PRK2 fragment". Biochemistry 41 (2): 561–9. doi:10.1021/bi010719z. PMID 11781095. 
  9. ^ Balendran A, Biondi RM, Cheung PC, Casamayor A, Deak M, Alessi DR (July 2000). "A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1". J. Biol. Chem. 275 (27): 20806–13. doi:10.1074/jbc.M000421200. PMID 10764742. 
  10. ^ Flynn P, Mellor H, Palmer R, Panayotou G, Parker PJ (January 1998). "Multiple interactions of PRK1 with RhoA. Functional assignment of the Hr1 repeat motif". J. Biol. Chem. 273 (5): 2698–705. doi:10.1074/jbc.273.5.2698. PMID 9446575.