From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
Aliases PLAGL1, LOT1, ZAC, ZAC1, PLAG1 like zinc finger 1
External IDs MGI: 1100874 HomoloGene: 31401 GeneCards: PLAGL1
Gene location (Human)
Chromosome 6 (human)
Chr. Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for PLAGL1
Genomic location for PLAGL1
Band 6q24.2 Start 143,940,300 bp[1]
End 144,064,599 bp[1]
RNA expression pattern
PBB GE PLAGL1 209318 x at fs.png

PBB GE PLAGL1 207002 s at fs.png

PBB GE PLAGL1 207943 x at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC) Chr 6: 143.94 – 144.06 Mb Chr 10: 13.06 – 13.13 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Zinc finger protein PLAGL1 is a protein that in humans is encoded by the PLAGL1 gene.[5][6][7]


This gene encodes a C2H2 zinc finger protein with transactivation and DNA-binding activity. This gene has been shown to exhibit antiproliferative activities and is a tumor suppressor gene candidate. Many transcript variants encoding two different isoforms have been found for this gene.[7]


PLAGL1 has been shown to interact with P53.[8]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000118495 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019817 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Kas K, Voz ML, Hensen K, Meyen E, Van de Ven WJ (Oct 1998). "Transcriptional activation capacity of the novel PLAG family of zinc finger proteins". J. Biol. Chem. 273 (36): 23026–32. doi:10.1074/jbc.273.36.23026. PMID 9722527. 
  6. ^ Varrault A, Ciani E, Apiou F, Bilanges B, Hoffmann A, Pantaloni C, Bockaert J, Spengler D, Journot L (Aug 1998). "hZAC encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancer". Proc. Natl. Acad. Sci. U.S.A. 95 (15): 8835–40. doi:10.1073/pnas.95.15.8835. PMC 21163Freely accessible. PMID 9671765. 
  7. ^ a b "Entrez Gene: PLAGL1 pleiomorphic adenoma gene-like 1". 
  8. ^ Huang SM, Schönthal AH, Stallcup MR (Apr 2001). "Enhancement of p53-dependent gene activation by the transcriptional coactivator Zac1". Oncogene. 20 (17): 2134–43. doi:10.1038/sj.onc.1204298. PMID 11360197. 

Further reading[edit]