PLAGL2

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PLAGL2
Identifiers
Aliases PLAGL2, ZNF900, PLAG1 like zinc finger 2
External IDs MGI: 1933165 HomoloGene: 1994 GeneCards: PLAGL2
Gene location (Human)
Chromosome 20 (human)
Chr. Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for PLAGL2
Genomic location for PLAGL2
Band 20q11.21 Start 32,192,503 bp[1]
End 32,207,791 bp[1]
RNA expression pattern
PBB GE PLAGL2 202925 s at fs.png

PBB GE PLAGL2 202924 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002657

NM_018807

RefSeq (protein)

NP_002648

NP_061277

Location (UCSC) Chr 20: 32.19 – 32.21 Mb Chr 20: 153.23 – 153.24 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Zinc finger protein PLAGL2 is a protein that in humans is encoded by the PLAGL2 gene.[5][6][7]

Zinc finger protein PLAGL2 is a zinc finger protein that recognizes DNA and/or RNA.[7]

The gene has seen in gliomas to suppress cellular differentiation and thus encourage cells to become more stem cell like. Such plasticity is seen in glioma cells, together with the ignorance to differentiation factors.[8]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000126003 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000051413 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Landrette SF, Kuo YH, Hensen K, Barjesteh van Waalwijk van Doorn-Khosrovani S, Perrat PN, Van de Ven WJ, Delwel R, Castilla LH (Mar 2005). "Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia in cooperation with Cbfb-MYH11". Blood. 105 (7): 2900–7. doi:10.1182/blood-2004-09-3630. PMID 15585652. 
  6. ^ Zheng G, Ning J, Yang YC (Oct 2007). "PLAGL2 controls the stability of Pirh2, an E3 ubiquitin ligase for p53". Biochem Biophys Res Commun. 364 (2): 344–50. doi:10.1016/j.bbrc.2007.10.003. PMC 2708094Freely accessible. PMID 17950244. 
  7. ^ a b "Entrez Gene: PLAGL2 pleiomorphic adenoma gene-like 2". 
  8. ^ Zheng H, Ying H, Wiedemeyer R, Yan H, Quayle SN, Ivanova EV, Paik JH, Zhang H, Xiao Y, Perry SR, Hu J, Vinjamoori A, Gan B, Sahin E, Chheda MG, Brennan C, Wang YA, Hahn WC, Chin L, DePinho RA (May 2010). "PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and glioma". Cancer Cell. 17 (5): 497–509. doi:10.1016/j.ccr.2010.03.020. PMC 2900858Freely accessible. PMID 20478531. 

Further reading[edit]