PLD2

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Phospholipase D2
Identifiers
Symbol PLD2
External IDs OMIM602384 MGI892877 HomoloGene55672 IUPHAR: 1434 ChEMBL: 2734 GeneCards: PLD2 Gene
EC number 3.1.4.4
RNA expression pattern
PBB GE PLD2 209643 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5338 18806
Ensembl ENSG00000129219 ENSMUSG00000020828
UniProt O14939 P97813
RefSeq (mRNA) NM_001243108 NM_008876
RefSeq (protein) NP_001230037 NP_032902
Location (UCSC) Chr 17:
4.71 – 4.73 Mb
Chr 11:
70.54 – 70.56 Mb
PubMed search [1] [2]

Phospholipase D2 is an enzyme that in humans is encoded by the PLD2 gene.[1][2]

Function[edit]

Phosphatidylcholine (PC)-specific phospholipases D (PLDs) catalyze the hydrolysis of PC to produce phosphatidic acid and choline. Activation of PC-specific PLDs occurs as a consequence of agonist stimulation of both tyrosine kinase and G protein-coupled receptors. PC-specific PLDs have been proposed to function in regulated secretion, cytoskeletal reorganization, transcriptional regulation, and cell cycle control.[supplied by OMIM][3]

Interactions[edit]

PLD2 has been shown to interact with:

Inhibitors[edit]

  • N-(2-(1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)-2-naphthamide: 75-fold selective versus PLD1, IC50 = 20 nM.[15]

References[edit]

  1. ^ Park SH, Ryu SH, Suh PG, Kim H (February 1999). "Assignment of human PLD2 to chromosome band 17p13.1 by fluorescence in situ hybridization". Cytogenet Cell Genet 82 (3–4): 225. doi:10.1159/000015106. PMID 9858823. 
  2. ^ Lopez I, Arnold RS, Lambeth JD (June 1998). "Cloning and initial characterization of a human phospholipase D2 (hPLD2). ADP-ribosylation factor regulates hPLD2". J Biol Chem 273 (21): 12846–52. doi:10.1074/jbc.273.21.12846. PMID 9582313. 
  3. ^ "Entrez Gene: PLD2 phospholipase D2". 
  4. ^ Lee S, Park JB, Kim JH, Kim Y, Kim JH, Shin KJ et al. (July 2001). "Actin directly interacts with phospholipase D, inhibiting its activity". J. Biol. Chem. 276 (30): 28252–60. doi:10.1074/jbc.M008521200. PMID 11373276. 
  5. ^ Park JB, Kim JH, Kim Y, Ha SH, Yoo JS, Du G et al. (July 2000). "Cardiac phospholipase D2 localizes to sarcolemmal membranes and is inhibited by alpha-actinin in an ADP-ribosylation factor-reversible manner". J. Biol. Chem. 275 (28): 21295–301. doi:10.1074/jbc.M002463200. PMID 10801846. 
  6. ^ Kim JH, Lee S, Kim JH, Lee TG, Hirata M, Suh PG et al. (March 2002). "Phospholipase D2 directly interacts with aldolase via Its PH domain". Biochemistry 41 (10): 3414–21. doi:10.1021/bi015700a. PMID 11876650. 
  7. ^ a b Lee C, Kim SR, Chung JK, Frohman MA, Kilimann MW, Rhee SG (June 2000). "Inhibition of phospholipase D by amphiphysins". J. Biol. Chem. 275 (25): 18751–8. doi:10.1074/jbc.M001695200. PMID 10764771. 
  8. ^ Zheng X, Bollinger Bollag W (December 2003). "Aquaporin 3 colocates with phospholipase d2 in caveolin-rich membrane microdomains and is downregulated upon keratinocyte differentiation". J. Invest. Dermatol. 121 (6): 1487–95. doi:10.1111/j.1523-1747.2003.12614.x. PMID 14675200. 
  9. ^ Czarny M, Fiucci G, Lavie Y, Banno Y, Nozawa Y, Liscovitch M (February 2000). "Phospholipase D2: functional interaction with caveolin in low-density membrane microdomains". FEBS Lett. 467 (2-3): 326–32. doi:10.1016/s0014-5793(00)01174-1. PMID 10675563. 
  10. ^ Kim JH, Lee S, Park JB, Lee SD, Kim JH, Ha SH et al. (June 2003). "Hydrogen peroxide induces association between glyceraldehyde 3-phosphate dehydrogenase and phospholipase D2 to facilitate phospholipase D2 activation in PC12 cells". J. Neurochem. 85 (5): 1228–36. doi:10.1046/j.1471-4159.2003.01755.x. PMID 12753082. 
  11. ^ Jang IH, Lee S, Park JB, Kim JH, Lee CS, Hur EM et al. (May 2003). "The direct interaction of phospholipase C-gamma 1 with phospholipase D2 is important for epidermal growth factor signaling". J. Biol. Chem. 278 (20): 18184–90. doi:10.1074/jbc.M208438200. PMID 12646582. 
  12. ^ Han JM, Kim JH, Lee BD, Lee SD, Kim Y, Jung YW et al. (March 2002). "Phosphorylation-dependent regulation of phospholipase D2 by protein kinase C delta in rat Pheochromocytoma PC12 cells". J. Biol. Chem. 277 (10): 8290–7. doi:10.1074/jbc.M108343200. PMID 11744693. 
  13. ^ Ahn BH, Kim SY, Kim EH, Choi KS, Kwon TK, Lee YH et al. (May 2003). "Transmodulation between phospholipase D and c-Src enhances cell proliferation". Mol. Cell. Biol. 23 (9): 3103–15. doi:10.1128/mcb.23.9.3103-3115.2003. PMC 153190. PMID 12697812. 
  14. ^ Kantonen S, Hatton N, Mahankali M, Henkels KM, Park H, Cox D et al. (November 2011). "A novel phospholipase D2-Grb2-WASp heterotrimer regulates leukocyte phagocytosis in a two-step mechanism". Mol. Cell. Biol. 31 (22): 4524–37. doi:10.1128/MCB.05684-11. PMC 3209255. PMID 21930784. 
  15. ^ Lavieri RR, Scott SA, Selvy PE, Kim K, Jadhav S, Morrison RD et al. (September 2010). "Design, Synthesis, and Biological Evaluation of Halogenated N-(2-(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)benzamides: Discovery of an Isoform-Selective Small Molecule Phospholipase D2 Inhibitor". J. Med. Chem. 53 (18): 6706–19. doi:10.1021/jm100814g. PMC 3179181. PMID 20735042. 

Further reading[edit]