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Available structures
PDB Ortholog search: PDBe RCSB
Aliases PLRG1, Cwc1, PRL1, PRP46, PRPF46, TANGO4, pleiotropic regulator 1
External IDs MGI: 1858197 HomoloGene: 2004 GeneCards: PLRG1
Gene location (Human)
Chromosome 4 (human)
Chr. Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for PLRG1
Genomic location for PLRG1
Band 4q31.3 Start 154,535,006 bp[1]
End 154,550,435 bp[1]
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 4: 154.54 – 154.55 Mb Chr 4: 83.06 – 83.07 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Pleiotropic regulator 1 is a protein that in humans is encoded by the PLRG1 gene.[5]


PLRG1 has been shown to interact with CDC5L.[6][7][8][9]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000171566 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027998 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ "Entrez Gene: PLRG1 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)". 
  6. ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. England. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948Freely accessible. PMID 17353931. 
  7. ^ Ajuh P, Lamond AI (November 2003). "Identification of peptide inhibitors of pre-mRNA splicing derived from the essential interaction domains of CDC5L and PLRG1". Nucleic Acids Res. England. 31 (21): 6104–16. doi:10.1093/nar/gkg817. PMC 275459Freely accessible. PMID 14576297. 
  8. ^ Ajuh P, Sleeman J, Chusainow J, Lamond AI (November 2001). "A direct interaction between the carboxyl-terminal region of CDC5L and the WD40 domain of PLRG1 is essential for pre-mRNA splicing". J. Biol. Chem. United States. 276 (45): 42370–81. doi:10.1074/jbc.M105453200. ISSN 0021-9258. PMID 11544257. 
  9. ^ Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846Freely accessible. PMID 11101529. 

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