PNRC1

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PNRC1
Identifiers
AliasesPNRC1, B4-2, PNAS-145, PROL2, PRR2, proline rich nuclear receptor coactivator 1
External IDsMGI: 1917838 HomoloGene: 4960 GeneCards: PNRC1
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for PNRC1
Genomic location for PNRC1
Band6q15Start89,080,751 bp[1]
End89,085,160 bp[1]
RNA expression pattern
PBB GE PNRC1 209034 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006813

NM_001033225

RefSeq (protein)

NP_006804

NP_001028397

Location (UCSC)Chr 6: 89.08 – 89.09 MbChr 4: 33.25 – 33.29 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Proline-rich nuclear receptor coactivator 1 is a protein that, in humans, is encoded by the PNRC1 gene.[5][6]

Function[edit]

PNRC1 functions as a coactivator for several nuclear receptors including AR, ERα, ERRα, ERRγ, GR, SF1, PR, TR, RAR and RXR.[7][8] The interaction between PNRC1 with nuclear receptors occurs through the SH3 domain of PNRC1.[8]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000146278 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040128 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Chen J, Liu L, Pohajdak B (Dec 1995). "Cloning a cDNA from human NK/T cells which codes for a protein with high proline content". Biochim Biophys Acta. 1264 (1): 19–22. doi:10.1016/0167-4781(95)00159-e. PMID 7578250. 
  6. ^ "Entrez Gene: PNRC1 proline-rich nuclear receptor coactivator 1". 
  7. ^ Zhou D, Quach KM, Yang C, Lee SY, Pohajdak B, Chen S (July 2000). "PNRC: a proline-rich nuclear receptor coregulatory protein that modulates transcriptional activation of multiple nuclear receptors including orphan receptors SF1 (steroidogenic factor 1) and ERRalpha1 (estrogen related receptor alpha-1)". Mol. Endocrinol. 14 (7): 986–98. doi:10.1210/me.14.7.986. PMID 10894149. 
  8. ^ a b Zhou D, Chen S (October 2001). "PNRC2 is a 16 kDa coactivator that interacts with nuclear receptors through an SH3-binding motif". Nucleic Acids Res. 29 (19): 3939–48. doi:10.1093/nar/29.19.3939. PMC 60244Freely accessible. PMID 11574675. 

Further reading[edit]

External links[edit]