POLE2

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POLE2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPOLE2, DPE2, polymerase (DNA) epsilon 2, accessory subunit, DNA polymerase epsilon 2, accessory subunit
External IDsMGI: 1197514 HomoloGene: 2015 GeneCards: POLE2
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for POLE2
Genomic location for POLE2
Band14q21.3Start49,643,555 bp[1]
End49,688,422 bp[1]
RNA expression pattern
PBB GE POLE2 205909 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001197330
NM_001197331
NM_002692
NM_001348384
NM_001348385

NM_011133

RefSeq (protein)

NP_001184259
NP_001184260
NP_002683
NP_001335313
NP_001335314

NP_035263

Location (UCSC)Chr 14: 49.64 – 49.69 MbChr 12: 69.2 – 69.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

DNA polymerase epsilon subunit 2 is an enzyme that in humans is encoded by the POLE2 gene.[5][6][7]

Interactions[edit]

POLE2 has been shown to interact with SAP18.[8]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100479 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020974 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Li Y, Asahara H, Patel VS, Zhou S, Linn S (Jan 1998). "Purification, cDNA cloning, and gene mapping of the small subunit of human DNA polymerase epsilon". J Biol Chem. 272 (51): 32337–44. doi:10.1074/jbc.272.51.32337. PMID 9405441.
  6. ^ Jokela M, Mäkiniemi M, Lehtonen S, Szpirer C, Hellman U, Syväoja JE (Mar 1998). "The small subunits of human and mouse DNA polymerase epsilon are homologous to the second largest subunit of the yeast Saccharomyces cerevisiae DNA polymerase epsilon". Nucleic Acids Res. 26 (3): 730–4. doi:10.1093/nar/26.3.730. PMC 147316. PMID 9443964.
  7. ^ "Entrez Gene: POLE2 polymerase (DNA directed), epsilon 2 (p59 subunit)".
  8. ^ Wada M, Miyazawa H, Wang RS, Mizuno T, Sato A, Asashima M, Hanaoka F (Mar 2002). "The second largest subunit of mouse DNA polymerase epsilon, DPE2, interacts with SAP18 and recruits the Sin3 co-repressor protein to DNA". J. Biochem. 131 (3): 307–11. doi:10.1093/oxfordjournals.jbchem.a003104. PMID 11872158.

Further reading[edit]