POLG2

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POLG2
Protein POLG2 PDB 2g4c.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases POLG2, HP55, MTPOLB, PEOA4, POLB, POLG-BETA, POLGB, polymerase (DNA) gamma 2, accessory subunit, DNA polymerase gamma 2, accessory subunit
External IDs MGI: 1354947 HomoloGene: 5221 GeneCards: POLG2
Gene location (Human)
Chromosome 17 (human)
Chr. Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for POLG2
Genomic location for POLG2
Band n/a Start 64,477,785 bp[1]
End 64,497,036 bp[1]
RNA expression pattern
PBB GE POLG2 205811 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007215

NM_015810
NM_001353435

RefSeq (protein)

NP_009146

NP_056625
NP_001340364

Location (UCSC) Chr 17: 64.48 – 64.5 Mb Chr 17: 106.77 – 106.78 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

DNA polymerase subunit gamma-2, mitochondrial is an protein that in humans is encoded by the POLG2 gene. The POLG2 gene encodes a 55 kDa accessory subunit protein that imparts high processivity and salt tolerance to the catalytic subunit of DNA polymerase gamma, encoded by the POLG gene.[5][6][7]


References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000256525 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020718 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Wang Y, Farr CL, Kaguni LS (Jul 1997). "Accessory subunit of mitochondrial DNA polymerase from Drosophila embryos. Cloning, molecular analysis, and association in the native enzyme". J Biol Chem. 272 (21): 13640–6. PMID 9153213. doi:10.1074/jbc.272.21.13640. 
  6. ^ "Entrez Gene: POLG2 polymerase (DNA directed), gamma 2, accessory subunit". 
  7. ^ Lim SE, Longley MJ, Copeland WC (1999). "The mitochondrial p55 accessory subunit of human DNA polymerase gamma enhances DNA binding, promotes processive DNA synthesis, and confers N-ethylmaleimide resistance". J. Biol. Chem. 274 (53): 38197–203. PMID 10608893. doi:10.1074/jbc.274.53.38197. 

Further reading[edit]