POLK

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POLK
Protein POLK PDB 1t94.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPOLK, DINB1, DINP, POLQ, polymerase (DNA) kappa, DNA polymerase kappa
External IDsOMIM: 605650 MGI: 1349767 HomoloGene: 32140 GeneCards: POLK
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for POLK
Genomic location for POLK
Band5q13.3Start75,511,756 bp[1]
End75,601,144 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016218
NM_001345921
NM_001345922

NM_012048

RefSeq (protein)

NP_001332850
NP_001332851
NP_057302
NP_057302.1

NP_001334531
NP_001334532
NP_001334533
NP_001334535
NP_036178

Location (UCSC)Chr 5: 75.51 – 75.6 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

DNA polymerase kappa is an DNA polymerase that in humans is encoded by the POLK gene. It is involved in translesion synthesis.[4][5][6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000122008 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Ohashi E, Ogi T, Kusumoto R, Iwai S, Masutani C, Hanaoka F, Ohmori H (Aug 2000). "Error-prone bypass of certain DNA lesions by the human DNA polymerase κ". Genes Dev. 14 (13): 1589–94. doi:10.1101/gad.14.13.1589. PMC 316741. PMID 10887153.
  5. ^ Gerlach VL, Aravind L, Gotway G, Schultz RA, Koonin EV, Friedberg EC (Nov 1999). "Human and mouse homologs of Escherichia coli DinB (DNA polymerase IV), members of the UmuC/DinB superfamily". Proc Natl Acad Sci U S A. 96 (21): 11922–7. doi:10.1073/pnas.96.21.11922. PMC 18388. PMID 10518552.
  6. ^ "Entrez Gene: POLK Polymerase (DNA directed) kappa".

Further reading[edit]