POLR2B

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POLR2B
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases POLR2B, POL2RB, RPB2, hRPB140, hsRPB2, polymerase (RNA) II subunit B
External IDs MGI: 2388280 HomoloGene: 722 GeneCards: POLR2B
RNA expression pattern
PBB GE POLR2B 201803 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001303269
NM_000938
NM_001303268

NM_153798

RefSeq (protein)

NP_000929
NP_001290197
NP_001290198

NP_722493.2
NP_722493

Location (UCSC) Chr 4: 56.98 – 57.03 Mb Chr 5: 77.31 – 77.35 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

DNA-directed RNA polymerase II subunit RPB2 is an enzyme that in humans is encoded by the POLR2B gene.[3][4]

This gene encodes the second largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit, in combination with at least two other polymerase subunits, forms a structure within the polymerase that maintains contact in the active site of the enzyme between the DNA template and the newly synthesized RNA.[5]

Interactions[edit]

POLR2B has been shown to interact with POLR2C,[6] POLR2E,[6] POLR2H[6] and POLR2L.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Acker J, Wintzerith M, Vigneron M, Kedinger C (October 1992). "Primary structure of the second largest subunit of human RNA polymerase II (or B)". J Mol Biol. 226 (4): 1295–9. doi:10.1016/0022-2836(92)91071-V. PMID 1518060. 
  4. ^ Acker J, Mattei MG, Wintzerith M, Roeckel N, Depetris D, Vigneron M, Kedinger C (August 1994). "Chromosomal localization of human RNA polymerase II subunit genes". Genomics. 20 (3): 496–9. doi:10.1006/geno.1994.1208. PMID 8034326. 
  5. ^ "Entrez Gene: POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa". 
  6. ^ a b c d Acker, J; de Graaff M; Cheynel I; Khazak V; Kedinger C; Vigneron M (July 1997). "Interactions between the human RNA polymerase II subunits". J. Biol. Chem. UNITED STATES. 272 (27): 16815–21. doi:10.1074/jbc.272.27.16815. ISSN 0021-9258. PMID 9201987. 

Further reading[edit]