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Available structures
PDB Ortholog search: PDBe RCSB
Aliases POLR2E, RPABC1, RPB5, XAP4, hRPB25, hsRPB5, polymerase (RNA) II subunit E, RNA polymerase II subunit E
External IDs MGI: 1913670 HomoloGene: 2018 GeneCards: POLR2E
Gene location (Human)
Chromosome 19 (human)
Chr. Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for POLR2E
Genomic location for POLR2E
Band 19p13.3 Start 1,086,579 bp[1]
End 1,095,380 bp[1]
RNA expression pattern
PBB GE POLR2E 217854 s at fs.png

PBB GE POLR2E 213887 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 19: 1.09 – 1.1 Mb Chr 10: 80.04 – 80.04 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

DNA-directed RNA polymerases I, II, and III subunit RPABC1 is a protein that in humans is encoded by the POLR2E gene.[5]

This gene encodes the fifth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases and is present in two-fold molar excess over the other polymerase subunits. An interaction between this subunit and a hepatitis virus transactivating protein has been demonstrated, suggesting that interaction between transcriptional activators and the polymerase can occur through this subunit. A pseudogene is located on chromosome 11.[6]


POLR2E has been shown to interact with TAF15,[7] POLR2C,[8] POLR2G,[8] POLR2H,[8] POLR2A,[8] POLR2B,[8] POLR2L[8] and GTF2F2.[9]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000099817 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004667 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Acker J, Mattei MG, Wintzerith M, Roeckel N, Depetris D, Vigneron M, Kedinger C (Aug 1994). "Chromosomal localization of human RNA polymerase II subunit genes". Genomics. 20 (3): 496–9. doi:10.1006/geno.1994.1208. PMID 8034326. 
  6. ^ "Entrez Gene: POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa". 
  7. ^ Bertolotti, A; Melot T; Acker J; Vigneron M; Delattre O; Tora L (Mar 1998). "EWS, but not EWS-FLI-1, is associated with both TFIID and RNA polymerase II: interactions between two members of the TET family, EWS and hTAFII68, and subunits of TFIID and RNA polymerase II complexes". Mol. Cell. Biol. UNITED STATES. 18 (3): 1489–97. doi:10.1128/mcb.18.3.1489. ISSN 0270-7306. PMC 108863Freely accessible. PMID 9488465. 
  8. ^ a b c d e f Acker, J; de Graaff M; Cheynel I; Khazak V; Kedinger C; Vigneron M (Jul 1997). "Interactions between the human RNA polymerase II subunits". J. Biol. Chem. UNITED STATES. 272 (27): 16815–21. doi:10.1074/jbc.272.27.16815. ISSN 0021-9258. PMID 9201987. 
  9. ^ Wei, W; Dorjsuren D; Lin Y; Qin W; Nomura T; Hayashi N; Murakami S (Apr 2001). "Direct interaction between the subunit RAP30 of transcription factor IIF (TFIIF) and RNA polymerase subunit 5, which contributes to the association between TFIIF and RNA polymerase II". J. Biol. Chem. United States. 276 (15): 12266–73. doi:10.1074/jbc.M009634200. ISSN 0021-9258. PMID 11278533. 

Further reading[edit]