POLR2F

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POLR2F
Protein POLR2F PDB 1qkl.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases POLR2F, HRBP14.4, POLRF, RPABC14.4, RPABC2, RPB14.4, RPB6, RPC15, polymerase (RNA) II subunit F
External IDs MGI: 1349393 HomoloGene: 7178 GeneCards: POLR2F
RNA expression pattern
PBB GE POLR2F 209511 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001301129
NM_001301130
NM_001301131
NM_021974

NM_027231

RefSeq (protein)

NP_001288058
NP_001288059
NP_001288060
NP_068809

NP_081507.1
NP_081507

Location (UCSC) Chr 22: 37.95 – 38.04 Mb Chr 15: 79.14 – 79.15 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

DNA-directed RNA polymerases I, II, and III subunit RPABC2 is a protein that in humans is encoded by the POLR2F gene.[3]

This gene encodes the sixth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes, that is also shared by the other two DNA-directed RNA polymerases. In yeast, this polymerase subunit, in combination with at least two other subunits, forms a structure that stabilizes the transcribing polymerase on the DNA template.[4]

Interactions[edit]

POLR2F has been shown to interact with POLR2C.[5]

See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Pusch C, Wang Z, Roe B, Blin N (September 1996). "Genomic structure of the RNA polymerase II small subunit (hRPB14.4) locus (POLRF) and mapping to 22q13.1 by sequence identity". Genomics. 34 (3): 440–2. doi:10.1006/geno.1996.0312. PMID 8786150. 
  4. ^ "Entrez Gene: POLR2F polymerase (RNA) II (DNA directed) polypeptide F". 
  5. ^ Acker, J; de Graaff M; Cheynel I; Khazak V; Kedinger C; Vigneron M (July 1997). "Interactions between the human RNA polymerase II subunits". J. Biol. Chem. UNITED STATES. 272 (27): 16815–21. doi:10.1074/jbc.272.27.16815. ISSN 0021-9258. PMID 9201987. 

Further reading[edit]