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Protein POLR2G PDB 2c35.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases POLR2G, RPB19, RPB7, hRPB19, hsRPB7, polymerase (RNA) II subunit G, RNA polymerase II subunit G
External IDs MGI: 1914960 HomoloGene: 2019 GeneCards: POLR2G
RNA expression pattern
PBB GE POLR2G 202306 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 11: 62.76 – 62.77 Mb Chr 19: 8.79 – 8.8 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

DNA-directed RNA polymerase II subunit RPB7 is an enzyme that in humans is encoded by the POLR2G gene.[3][4]

This gene encodes the seventh largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, the association of this subunit with the polymerase under suboptimal growth conditions indicates it may play a role in regulating polymerase function.[5]


POLR2G has been shown to interact with TAF15,[6] POLR2C,[7] POLR2H[7] and POLR2E.[7]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Khazak V, Sadhale PP, Woychik NA, Brent R, Golemis EA (December 1995). "Human RNA polymerase II subunit hsRPB7 functions in yeast and influences stress survival and cell morphology". Mol Biol Cell. 6 (7): 759–75. doi:10.1091/mbc.6.7.759. PMC 301239Freely accessible. PMID 7579693. 
  4. ^ Schoen TJ, Chandrasekharappa SC, Guru SC, Mazuruk K, Chader GJ, Rodriguez IR (August 1997). "Human gene for the RNA polymerase II seventh subunit (hsRPB7): structure, expression and chromosomal localization". Biochim Biophys Acta. 1353 (1): 39–49. doi:10.1016/s0167-4781(97)00041-9. PMID 9256063. 
  5. ^ "Entrez Gene: POLR2G polymerase (RNA) II (DNA directed) polypeptide G". 
  6. ^ Bertolotti, A; Melot T; Acker J; Vigneron M; Delattre O; Tora L (March 1998). "EWS, but not EWS-FLI-1, is associated with both TFIID and RNA polymerase II: interactions between two members of the TET family, EWS and hTAFII68, and subunits of TFIID and RNA polymerase II complexes". Mol. Cell. Biol. UNITED STATES. 18 (3): 1489–97. ISSN 0270-7306. PMC 108863Freely accessible. PMID 9488465. 
  7. ^ a b c Acker, J; de Graaff M; Cheynel I; Khazak V; Kedinger C; Vigneron M (July 1997). "Interactions between the human RNA polymerase II subunits". J. Biol. Chem. UNITED STATES. 272 (27): 16815–21. doi:10.1074/jbc.272.27.16815. ISSN 0021-9258. PMID 9201987. 

Further reading[edit]