POLR2I

From Wikipedia, the free encyclopedia
Jump to: navigation, search
POLR2I
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases POLR2I, RPB9, hRPB14.5, polymerase (RNA) II subunit I, RNA polymerase II subunit I
External IDs MGI: 1917170 HomoloGene: 4541 GeneCards: POLR2I
RNA expression pattern
PBB GE POLR2I 212955 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006233

NM_027259

RefSeq (protein)

NP_006224

NP_081535.1
NP_081535

Location (UCSC) Chr 19: 36.11 – 36.12 Mb Chr 7: 30.23 – 30.23 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

DNA-directed RNA polymerase II subunit RPB9 is an enzyme that in humans is encoded by the POLR2I gene.[3]

This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit, in combination with two other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. The product of this gene has two zinc finger motifs with conserved cysteines and the subunit does possess zinc binding activity.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Acker J, Mattei MG, Wintzerith M, Roeckel N, Depetris D, Vigneron M, Kedinger C (Aug 1994). "Chromosomal localization of human RNA polymerase II subunit genes". Genomics. 20 (3): 496–9. doi:10.1006/geno.1994.1208. PMID 8034326. 
  4. ^ "Entrez Gene: POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa". 

Further reading[edit]