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Protein POU2AF1 PDB 1cqt.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases POU2AF1, BOB1, OBF-1, OBF1, OCAB, POU class 2 associating factor 1
External IDs MGI: 105086 HomoloGene: 4543 GeneCards: POU2AF1
RNA expression pattern
PBB GE POU2AF1 205267 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 11: 111.35 – 111.46 Mb Chr 9: 51.21 – 51.24 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

POU domain class 2-associating factor 1 is a protein that in humans is encoded by the POU2AF1 gene.[3][4]


POU2AF1 has been shown to interact with:


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Junker S, Brøndum-Nielsen K, Newell JW, Matthias P, Tommerup N (Jun 1996). "Assignment of the human gene for Oct-binding factor-1 (OBF1), a B-cell-specific coactivator of octamer-binding transcription factors 1 and 2, to 11q23.1 by somatic cell hybridization and in situ hybridization". Genomics. 33 (1): 143–5. doi:10.1006/geno.1996.0173. PMID 8617501. 
  4. ^ "Entrez Gene: POU2AF1 POU domain, class 2, associating factor 1". 
  5. ^ Chasman D, Cepek K, Sharp PA, Pabo CO (Oct 1999). "Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface". Genes Dev. 13 (20): 2650–7. doi:10.1101/gad.13.20.2650. PMC 317104Freely accessible. PMID 10541551. 
  6. ^ Wong MW, Henry RW, Ma B, Kobayashi R, Klages N, Matthias P, Strubin M, Hernandez N (Jan 1998). "The large subunit of basal transcription factor SNAPc is a Myb domain protein that interacts with Oct-1". Mol. Cell. Biol. 18 (1): 368–77. doi:10.1128/mcb.18.1.368. PMC 121507Freely accessible. PMID 9418884. 
  7. ^ Lee L, Stollar E, Chang J, Grossmann JG, O'Brien R, Ladbury J, Carpenter B, Roberts S, Luisi B (Jun 2001). "Expression of the Oct-1 transcription factor and characterization of its interactions with the Bob1 coactivator". Biochemistry. 40 (22): 6580–8. doi:10.1021/bi010095x. PMID 11380252. 
  8. ^ Tiedt R, Bartholdy BA, Matthias G, Newell JW, Matthias P (Aug 2001). "The RING finger protein Siah-1 regulates the level of the transcriptional coactivator OBF-1". EMBO J. 20 (15): 4143–52. doi:10.1093/emboj/20.15.4143. PMC 149178Freely accessible. PMID 11483517. 

Further reading[edit]