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POU class 3 homeobox 2
Symbols POU3F2 ; BRN2; N-Oct3; OCT7; OTF-7; OTF7; POUF3; brn-2; oct-7
External IDs OMIM600494 MGI101895 HomoloGene4095 ChEMBL: 4189 GeneCards: POU3F2 Gene
RNA expression pattern
PBB GE POU3F2 207084 at tn.png
More reference expression data
Species Human Mouse
Entrez 5454 18992
Ensembl ENSG00000184486 ENSMUSG00000095139
UniProt P20265 P31360
RefSeq (mRNA) NM_005604 NM_008899
RefSeq (protein) NP_005595 NP_032925
Location (UCSC) Chr 6:
98.83 – 98.84 Mb
Chr 4:
22.48 – 22.49 Mb
PubMed search [1] [2]

POU domain, class 3, transcription factor 2 is a protein that in humans is encoded by the POU3F2 gene.[1][2]


N-Oct-3 is a protein belonging to a large family of transcription factors that bind to the octameric DNA sequence ATGCAAAT. Most of these proteins share a highly homologous region, referred to as the POU domain, which occurs in several mammalian transcription factors, including the octamer-binding proteins Oct1 (POU2F1; MIM 164175) and Oct2 (POU2F2; MIM 164176), and the pituitary protein Pit1 (PIT1; MIM 173110). Class III POU genes are expressed predominantly in the CNS. It is likely that CNS-specific transcription factors such as these play an important role in mammalian neurogenesis by regulating their diverse patterns of gene expression.[supplied by OMIM][2]

Disease Linkage[edit]

The POU3F2 protein associates with the Bipolar disorder. Is involved in the neocortex development in mice, and is linked to a single nucletide polimorfism,Rs1906252, that is associated with a cognitive phenotype: processing information speed.[3]


POU3F2 has been shown to interact with PQBP1.[4]

See also[edit]


  1. ^ Schreiber E, Tobler A, Malipiero U, Schaffner W, Fontana A (Mar 1993). "cDNA cloning of human N-Oct3, a nervous-system specific POU domain transcription factor binding to the octamer DNA motif". Nucleic Acids Res 21 (2): 253–8. doi:10.1093/nar/21.2.253. PMC 309100. PMID 8441633. 
  2. ^ a b "Entrez Gene: POU3F2 POU domain, class 3, transcription factor 2". 
  3. ^ "Genome-wide association study reveals two new risk loci for bipolar disorder". 
  4. ^ Waragai M, Lammers CH, Takeuchi S, Imafuku I, Udagawa Y, Kanazawa I, Kawabata M, Mouradian MM, Okazawa H (Jun 1999). "PQBP-1, a novel polyglutamine tract-binding protein, inhibits transcription activation by Brn-2 and affects cell survival". Hum. Mol. Genet. 8 (6): 977–87. doi:10.1093/hmg/8.6.977. PMID 10332029. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.