N-Oct-3 is a protein belonging to a large family of transcription factors that bind to the octameric DNA sequence ATGCAAAT. Most of these proteins share a highly homologous region, referred to as the POU domain, which occurs in several mammalian transcription factors, including the octamer-binding proteins Oct1 (POU2F1; MIM 164175) and Oct2 (POU2F2; MIM 164176), and the pituitary protein Pit1 (PIT1; MIM 173110). Class III POU genes are expressed predominantly in the CNS. It is likely that CNS-specific transcription factors such as these play an important role in mammalian neurogenesis by regulating their diverse patterns of gene expression.[supplied by OMIM]
The POU3F2 protein associates with the Bipolar disorder. Is involved in the neocortex development in mice, and is linked to a single nucletide polymorphism, Rs1906252, that is associated with a cognitive phenotype: processing information speed.
^Waragai M, Lammers CH, Takeuchi S, Imafuku I, Udagawa Y, Kanazawa I, Kawabata M, Mouradian MM, Okazawa H (Jun 1999). "PQBP-1, a novel polyglutamine tract-binding protein, inhibits transcription activation by Brn-2 and affects cell survival". Hum. Mol. Genet.8 (6): 977–87. doi:10.1093/hmg/8.6.977. PMID10332029.
He X, Treacy MN, Simmons DM, Ingraham HA, Swanson LW, Rosenfeld MG (1989). "Expression of a large family of POU-domain regulatory genes in mammalian brain development.". Nature340 (6228): 35–41. doi:10.1038/340035a0. PMID2739723.
Eisen T, Easty DJ, Bennett DC, Goding CR (1995). "The POU domain transcription factor Brn-2: elevated expression in malignant melanoma and regulation of melanocyte-specific gene expression.". Oncogene11 (10): 2157–64. PMID7478537.
Atanasoski S, Toldo SS, Malipiero U, Schreiber E, Fries R, Fontana A (1995). "Isolation of the human genomic brain-2/N-Oct 3 gene (POUF3) and assignment to chromosome 6q16.". Genomics26 (2): 272–80. doi:10.1016/0888-7543(95)80211-4. PMID7601453.
Thomson JA, Murphy K, Baker E, Sutherland GR, Parsons PG, Sturm RA, Thomson F (1995). "The brn-2 gene regulates the melanocytic phenotype and tumorigenic potential of human melanoma cells.". Oncogene11 (4): 691–700. PMID7651733.
Atanasoski S, Schreiber E, Fontana A, Herr W (1997). "N-Oct 5 is generated by in vitro proteolysis of the neural POU-domain protein N-Oct 3.". Oncogene14 (11): 1287–94. doi:10.1038/sj.onc.1200953. PMID9178889.
Petersenn S, Rasch AC, Heyens M, Schulte HM (1998). "Structure and regulation of the human growth hormone-releasing hormone receptor gene.". Mol. Endocrinol.12 (2): 233–47. doi:10.1210/me.12.2.233. PMID9482665.
Kuhlbrodt K, Herbarth B, Sock E, Enderich J, Hermans-Borgmeyer I, Wegner M (1998). "Cooperative function of POU proteins and SOX proteins in glial cells.". J. Biol. Chem.273 (26): 16050–7. doi:10.1074/jbc.273.26.16050. PMID9632656.
Waragai M, Lammers CH, Takeuchi S, Imafuku I, Udagawa Y, Kanazawa I, Kawabata M, Mouradian MM, Okazawa H (1999). "PQBP-1, a novel polyglutamine tract-binding protein, inhibits transcription activation by Brn-2 and affects cell survival.". Hum. Mol. Genet.8 (6): 977–87. doi:10.1093/hmg/8.6.977. PMID10332029.
Smit DJ, Smith AG, Parsons PG, Muscat GE, Sturm RA (2000). "Domains of Brn-2 that mediate homodimerization and interaction with general and melanocytic transcription factors.". Eur. J. Biochem.267 (21): 6413–22. doi:10.1046/j.1432-1327.2000.01737.x. PMID11029584.