POU3F2

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POU3F2
Identifiers
Aliases POU3F2, BRN2, N-Oct3, OCT7, OTF-7, OTF7, POUF3, brn-2, oct-7, POU class 3 homeobox 2
External IDs MGI: 101895 HomoloGene: 4095 GeneCards: 5454
RNA expression pattern
PBB GE POU3F2 207084 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005604

NM_008899

RefSeq (protein)

NP_005595.2

NP_032925.1

Location (UCSC) Chr 6: 98.83 – 98.84 Mb Chr 4: 22.48 – 22.49 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

POU domain, class 3, transcription factor 2 is a protein that in humans is encoded by the POU3F2 gene.[1][2]

Function[edit]

N-Oct-3 is a protein belonging to a large family of transcription factors that bind to the octameric DNA sequence ATGCAAAT. Most of these proteins share a highly homologous region, referred to as the POU domain, which occurs in several mammalian transcription factors, including the octamer-binding proteins Oct1 (POU2F1; MIM 164175) and Oct2 (POU2F2; MIM 164176), and the pituitary protein Pit1 (PIT1; MIM 173110). Class III POU genes are expressed predominantly in the CNS. It is likely that CNS-specific transcription factors such as these play an important role in mammalian neurogenesis by regulating their diverse patterns of gene expression.[supplied by OMIM][2]

Disease Linkage[edit]

The POU3F2 protein associates with the Bipolar disorder. Is involved in the neocortex development in mice, and is linked to a single nucletide polymorphism, Rs1906252, that is associated with a cognitive phenotype: processing information speed.[3]

Interactions[edit]

POU3F2 has been shown to interact with PQBP1.[4]

See also[edit]

References[edit]

  1. ^ Schreiber E, Tobler A, Malipiero U, Schaffner W, Fontana A (Mar 1993). "cDNA cloning of human N-Oct3, a nervous-system specific POU domain transcription factor binding to the octamer DNA motif". Nucleic Acids Res 21 (2): 253–8. doi:10.1093/nar/21.2.253. PMC 309100. PMID 8441633. 
  2. ^ a b "Entrez Gene: POU3F2 POU domain, class 3, transcription factor 2". 
  3. ^ "Genome-wide association study reveals two new risk loci for bipolar disorder". 
  4. ^ Waragai M, Lammers CH, Takeuchi S, Imafuku I, Udagawa Y, Kanazawa I, Kawabata M, Mouradian MM, Okazawa H (Jun 1999). "PQBP-1, a novel polyglutamine tract-binding protein, inhibits transcription activation by Brn-2 and affects cell survival". Hum. Mol. Genet. 8 (6): 977–87. doi:10.1093/hmg/8.6.977. PMID 10332029. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.