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POU class 4 homeobox 2
Symbols POU4F2 ; BRN3.2; BRN3B; Brn-3b
External IDs OMIM113725 MGI102524 HomoloGene20959 GeneCards: POU4F2 Gene
RNA expression pattern
PBB GE POU4F2 207725 at tn.png
More reference expression data
Species Human Mouse
Entrez 5458 18997
Ensembl ENSG00000151615 ENSMUSG00000031688
UniProt Q12837 Q63934
RefSeq (mRNA) NM_004575 NM_138944
RefSeq (protein) NP_004566 NP_620394
Location (UCSC) Chr 4:
146.64 – 146.64 Mb
Chr 8:
78.43 – 78.44 Mb
PubMed search [1] [2]

POU domain, class 4, transcription factor 2 is a protein that in humans is encoded by the POU4F2 gene.[1][2]

POU4F2 is a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. A class IV POU-domain protein, POU4F2 is found in human retina exclusively within a subpopulation of ganglion cells where it may play a role in determining or maintaining the identities of a small subset of visual system neurons.[supplied by OMIM][2]


POU4F2 has been shown to interact with Estrogen receptor alpha.[3]

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.