PPIH

From Wikipedia, the free encyclopedia
Jump to: navigation, search
PPIH
Protein PPIH PDB 1mzw.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PPIH, CYP-20, CYPH, SnuCyp-20, USA-CYP, peptidylprolyl isomerase H
External IDs MGI: 106499 HomoloGene: 38172 GeneCards: PPIH
RNA expression pattern
PBB GE PPIH 204228 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006347
NM_001330510

NM_001110129
NM_001110130
NM_028677

RefSeq (protein)

NP_001317439
NP_006338

Location (UCSC) Chr 1: 42.66 – 42.68 Mb Chr 4: 119.3 – 119.32 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Peptidyl-prolyl cis-trans isomerase H is an enzyme that in humans is encoded by the PPIH gene.[3][4][5]

The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. This protein has been shown to possess PPIase activity and may act as a protein chaperone that mediates the interactions between different proteins inside the spliceosome.[5]

References[edit]

Further reading[edit]