From Wikipedia, the free encyclopedia
Jump to: navigation, search
Protein PPM1A PDB 1a6q.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases PPM1A, PP2C-ALPHA, PP2CA, PP2Calpha, protein phosphatase, Mg2+/Mn2+ dependent 1A
External IDs MGI: 99878 HomoloGene: 56428 GeneCards: PPM1A
Gene location (Human)
Chromosome 14 (human)
Chr. Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for PPM1A
Genomic location for PPM1A
Band 14q23.1 Start 60,245,752 bp[1]
End 60,299,087 bp[1]
RNA expression pattern
PBB GE PPM1A 203966 s at fs.png

PBB GE PPM1A 210407 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 14: 60.25 – 60.3 Mb Chr 12: 72.76 – 72.8 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Protein phosphatase 1A is an enzyme that in humans is encoded by the PPM1A gene.[5][6]

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding two distinct isoforms have been described.[6]


PPM1A has been shown to interact with Metabotropic glutamate receptor 3.[7] In 2006, Dr. Feng found that PPM1A can terminate TGF-beta signaling by inactivating Smad3 via dephosphorylation. Smad3 is an essential component of the TGF-beta signalling pathway.


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100614 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021096 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Mann DJ, Campbell DG, McGowan CH, Cohen PT (Apr 1992). "Mammalian protein serine/threonine phosphatase 2C: cDNA cloning and comparative analysis of amino acid sequences". Biochim Biophys Acta. 1130 (1): 100–4. doi:10.1016/0167-4781(92)90471-b. PMID 1311954. 
  6. ^ a b "Entrez Gene: PPM1A protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform". 
  7. ^ Flajolet, Marc; Rakhilin Sergey; Wang Hong; Starkova Natalia; Nuangchamnong Nina; Nairn Angus C; Greengard Paul (Dec 2003). "Protein phosphatase 2C binds selectively to and dephosphorylates metabotropic glutamate receptor 3". Proc. Natl. Acad. Sci. U.S.A. United States. 100 (26): 16006–11. doi:10.1073/pnas.2136600100. ISSN 0027-8424. PMC 307683Freely accessible. PMID 14663150. 

Further reading[edit]