PPP1R10

PPP1R10
Identifiers
Aliases	PPP1R10, CAT53, FB19, PNUTS, PP1R10, R111, p99, protein phosphatase 1 regulatory subunit 10
External IDs	OMIM: 603771; MGI: 1289273; HomoloGene: 2033; GeneCards: PPP1R10; OMA:PPP1R10 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6p21.33 Start 30,600,413 bp End 30,618,612 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17 B1|17 18.77 cM Start 36,227,326 bp End 36,243,175 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bone marrow cells sural nerve gallbladder tonsil granulocyte appendix urinary bladder right uterine tube rectum Achilles tendon Top expressed in primary oocyte zygote tail of embryo testicle secondary oocyte genital tubercle spermatid spermatocyte ventricular zone uterus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein phosphatase inhibitor activity DNA binding metal ion binding RNA binding protein binding Cellular component chromatin PTW/PP1 phosphatase complex nucleus nucleoplasm nuclear body Biological process negative regulation of catalytic activity protein import into nucleus negative regulation of cardiac muscle cell apoptotic process positive regulation of telomere maintenance negative regulation of phosphoprotein phosphatase activity negative regulation of mitotic DNA damage checkpoint Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5514 52040 Ensembl ENSG00000227804 ENSG00000238104 ENSG00000206489 ENSG00000230995 ENSG00000235291 ENSG00000231737 ENSG00000204569 ENSMUSG00000039220 UniProt Q96QC0 Q80W00 RefSeq (mRNA) NM_002714 NM_001376195 NM_001163818 NM_175934 NM_001357740 RefSeq (protein) NP_002705 NP_001363124 NP_001157290 NP_001344669 NP_001390493 Location (UCSC) Chr 6: 30.6 – 30.62 Mb Chr 17: 36.23 – 36.24 Mb PubMed search
Wikidata
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Serine/threonine-protein phosphatase 1 regulatory subunit 10 is an enzyme that in humans is encoded by the PPP1R10 gene. This gene lies within the major histocompatibility complex class I region on chromosome 6.

Function

This gene encodes a protein with similarity to a rat protein that has an inhibitory effect on protein phosphatase-1 (PP1). The rat protein localizes to the nucleus and colocalizes with chromatin at distinct phases during mitosis.

Further reading

• Totaro A, Rommens JM, Grifa A, et al. (1997). "Hereditary hemochromatosis: generation of a transcription map within a refined and extended map of the HLA class I region". Genomics. 31 (3): 319–26. doi:10.1006/geno.1996.0054. PMID 8838313.
• Kreivi JP, Trinkle-Mulcahy L, Lyon CE, et al. (1998). "Purification and characterisation of p99, a nuclear modulator of protein phosphatase 1 activity". FEBS Lett. 420 (1): 57–62. doi:10.1016/S0014-5793(97)01485-3. PMID 9450550.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kim YM, Watanabe T, Allen PB, et al. (2003). "PNUTS, a protein phosphatase 1 (PP1) nuclear targeting subunit. Characterization of its PP1- and RNA-binding domains and regulation by phosphorylation". J. Biol. Chem. 278 (16): 13819–28. doi:10.1074/jbc.M209621200. PMID 12574161.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Reeder JE, Sowden MP, Messing EM, et al. (2003). "Inducible expression of catalytically active type 1 serine/threonine protein phosphatase in a human carcinoma cell line". Cancer Cell International. 3 (1): 12. doi:10.1186/1475-2867-3-12. PMC 183861. PMID 12914669.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Raha-Chowdhury R, Andrews SR, Gruen JR (2005). "CAT 53: a protein phosphatase 1 nuclear targeting subunit encoded in the MHC Class I region strongly expressed in regions of the brain involved in memory, learning, and Alzheimer's disease". Brain Res. Mol. Brain Res. 138 (1): 70–83. doi:10.1016/j.molbrainres.2005.04.001. PMID 15894402.
• Landsverk HB, Kirkhus M, Bollen M, et al. (2006). "PNUTS enhances in vitro chromosome decondensation in a PP1-dependent manner". Biochem. J. 390 (Pt 3): 709–17. doi:10.1042/BJ20050678. PMC 1199665. PMID 15907195.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Lee SJ, Lim CJ, Min JK, et al. (2007). "Protein phosphatase 1 nuclear targeting subunit is a hypoxia inducible gene: its role in post-translational modification of p53 and MDM2". Cell Death Differ. 14 (6): 1106–16. doi:10.1038/sj.cdd.4402111. PMID 17318220.