PPP1R8

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PPP1R8
Protein PPP1R8 PDB 2jpe.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PPP1R8, ARD-1, ARD1, NIPP-1, NIPP1, PRO2047, protein phosphatase 1 regulatory subunit 8
External IDs MGI: 2140494 HomoloGene: 8555 GeneCards: PPP1R8
RNA expression pattern
PBB GE PPP1R8 207830 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_138558
NM_002713
NM_014110

NM_001290725
NM_146154

RefSeq (protein)

NP_002704
NP_054829
NP_612568

NP_001277654.1
NP_666266.1
NP_001277654
NP_666266

Location (UCSC) Chr 1: 27.83 – 27.85 Mb Chr 4: 132.83 – 132.84 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Nuclear inhibitor of protein phosphatase 1 is an enzyme that in humans is encoded by the PPP1R8 gene.[3][4][5]

This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA.[5]

Interactions[edit]

PPP1R8 has been shown to interact with PPP1CA,[6][7] Histone deacetylase 2,[6] SF3B1[8] and EED.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Wang M, Cohen SN (November 1994). "ard-1: a human gene that reverses the effects of temperature-sensitive and deletion mutations in the Escherichia coli rne gene and encodes an activity producing RNase E-like cleavages". Proc Natl Acad Sci USA. 91 (22): 10591–5. doi:10.1073/pnas.91.22.10591. PMC 45067Freely accessible. PMID 7524097. 
  4. ^ Mishima K, Tsuchiya M, Nightingale MS, Moss J, Vaughan M (May 1993). "ARD 1, a 64-kDa guanine nucleotide-binding protein with a carboxyl-terminal ADP-ribosylation factor domain". J Biol Chem. 268 (12): 8801–7. PMID 8473324. 
  5. ^ a b "Entrez Gene: PPP1R8 protein phosphatase 1, regulatory (inhibitor) subunit 8". 
  6. ^ a b c Jin, Qiming; van Eynde Aleyde; Beullens Monique; Roy Nivedita; Thiel Gerald; Stalmans Willy; Bollen Mathieu (August 2003). "The protein phosphatase-1 (PP1) regulator, nuclear inhibitor of PP1 (NIPP1), interacts with the polycomb group protein, embryonic ectoderm development (EED), and functions as a transcriptional repressor". J. Biol. Chem. United States. 278 (33): 30677–85. doi:10.1074/jbc.M302273200. ISSN 0021-9258. PMID 12788942. 
  7. ^ Ajuh, P M; Browne G J; Hawkes N A; Cohen P T; Roberts S G; Lamond A I (February 2000). "Association of a protein phosphatase 1 activity with the human factor C1 (HCF) complex". Nucleic Acids Res. ENGLAND. 28 (3): 678–86. doi:10.1093/nar/28.3.678. PMC 102561Freely accessible. PMID 10637318. 
  8. ^ Boudrez, An; Beullens Monique; Waelkens Etienne; Stalmans Willy; Bollen Mathieu (August 2002). "Phosphorylation-dependent interaction between the splicing factors SAP155 and NIPP1". J. Biol. Chem. United States. 277 (35): 31834–41. doi:10.1074/jbc.M204427200. ISSN 0021-9258. PMID 12105215. 

Further reading[edit]